Evidence map›Paper›PMID 33814437›Full record

Trial reportJournal of Alzheimer's disease : JAD2021

β-Lactolin Enhances Neural Activity, Indicated by Event-Related P300 Amplitude, in Healthy Adults: A Randomized Controlled Trial.

Ayana Kanatome, Yasuhisa Ano, Kazushi Shinagawa, Yumiko Ide, Midori Shibata, Satoshi Umeda

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayana KanatomeKirin Central Research Institute, Kirin Holdings Company, Ltd., Fujisawa, Kanagawa, Japan.
Yasuhisa AnoKirin Central Research Institute, Kirin Holdings Company, Ltd., Fujisawa, Kanagawa, Japan.
Kazushi ShinagawaDepartment of Psychology, Keio University, Mita, Minato-ku, Tokyo, Japan.
Yumiko IdeTokyo Center Clinic, Chuo-ku, Tokyo, Japan.
Midori ShibataDepartment of Psychology, Keio University, Mita, Minato-ku, Tokyo, Japan.
Satoshi UmedaDepartment of Psychology, Keio University, Mita, Minato-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiological studies have shown that dairy product consumption is beneficial for cognitive function in elderly individuals. β-lactolin is a Gly-Thr-Trp-Tyr lacto-tetrapeptide rich in fermented dairy products that improves memory retrieval, attention, and executive function in older adults with subjective cognitive decline and prevents the pathology of Alzheimer's disease in rodents. There has been no study on the effects of β-lactolin on neural activity in humans.

objectiveWe investigated the effects of β-lactolin on neural activity and cognitive function in healthy adults.

methodsIn this randomized, double-blind, placebo-controlled study, 30 participants (45-64 years old) consumed β-lactolin or placebo for 6 weeks. Neural activity during auditory and language tasks was measured through 64-channel electroencephalography. Moreover, verbal fluency tests were performed at baseline and after 6 weeks.

resultsThe β-lactolin group had a significantly higher P300 amplitude at the Cp2 site (a part of the parietal lobe near the center of brain, p = 0.011), and C4 site (the area between the frontal and parietal lobe, p = 0.02) during the auditory tasks after 6 weeks than the placebo group. Thus, β-lactolin supplementation promoted neural activity in the parietal area, which increases concentration and attention during auditory cognitive tasks. Compared with the placebo group, the β-lactolin group also showed significant changes in the scores of verbal fluency test after 6 weeks (p = 0.033).

conclusionOur findings provide insight into the mechanisms underlying the effects of β-lactolin on attention in healthy adults.

Indexed as

Alzheimer DiseaseCognitionExecutive FunctionMemoryOligopeptidesWhey ProteinsAttentionDouble-Blind MethodFemaleHumansMaleMiddle AgedParietal Lobebeta-lactolinOligopeptidesWhey Proteinsattentionclinical trialcognitive functionEEGmemoryP300wheyβ-lactoglobulinβ-lactolinβ-lactopeptide

Identifiers

PMID33814437
PMCPMC8203246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.