ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2021
Single individual structural variant detection uncovers widespread hemizygosity in molluscs.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- The highly dynamic pangenome of basal chordates is enriched in defence and immunity genes and is inherited following the Mendelian law.PLoS genetics · 2025Article
- Widespread HCD-tRNA derived SINEs in bivalves rely on multiple LINE partners and accumulate in genic regions.Mobile DNA · 2024Article
- Chromosomal-scale genome assembly of the Mediterranean mussel Mytilus galloprovincialis.Scientific data · 2024Article
- Gene presence/absence variation iniScience · 2023Article
- Multiple and diversified transposon lineages contribute to early and recent bivalve genome evolution.BMC biology · 2023Article
- SNP discovery and genetic structure in blue mussel species using low coverage sequencing and a medium density 60 K SNP-array.Evolutionary applications · 2023Article
- A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves.Marine drugs · 2023Article
- A chromosome-level assembly supports genome-wide investigation of the DMRT gene family in the golden mussel (Limnoperna fortunei).GigaScience · 2022Article
- Expansion and Neofunctionalization of Actinoporin-like Genes in Mediterranean Mussel (Mytilus galloprovincialis).Genome biology and evolution · 2022Article
- Two parallel chromosome-level reference genomes to support restoration and aquaculture of European flat oysterEvolutionary applications · 2022Article
- A butterfly pan-genome reveals that a large amount of structural variation underlies the evolution of chromatin accessibility.Genome research · 2022Article
- IntraspecificNAR genomics and bioinformatics · 2022Article
- Comparative analysis of novel and common reference genes in adult tissues of the mussel Mytilus galloprovincialis.BMC genomics · 2022Article
- ADAR-Editing during Ostreid Herpesvirus 1 Infection inmSphere · 2022Article
- ChromoMap: an R package for interactive visualization of multi-omics data and annotation of chromosomes.BMC bioinformatics · 2022Article
- Pearls of wisdom-a Theo Murphy issue on molluscan genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Chromosome-level genome assembly of the hard-shelled mussel Mytilus coruscus, a widely distributed species from the temperate areas of East Asia.GigaScience · 2021Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advent of complete genomic sequencing has opened a window into genomic phenomena obscured by fragmented assemblies. A good example of these is the existence of hemizygous regions of autosomal chromosomes, which can result in marked differences in gene content between individuals within species. While these hemizygous regions, and presence/absence variation of genes that can result, are well known in plants, firm evidence has only recently emerged for their existence in metazoans. Here, we use recently published, complete genomes from wild-caught molluscs to investigate the prevalence of hemizygosity across a well-known and ecologically important clade. We show that hemizygous regions are widespread in mollusc genomes, not clustered in individual chromosomes, and often contain genes linked to transposition, DNA repair and stress response. With targeted investigations of
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