Evidence map›Paper›PMID 33813880›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2021

Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance.

Cody D Smith, Chien-Te Lin, Shawna L McMillin, Luke A Weyrauch, Cameron A Schmidt, Cheryl A Smith, Irwin J Kurland, Carol A Witczak, P Darrell Neufer

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Multiple Roles of Palmitic Acid in Cardiovascular Diseases.Journal of inflammation research · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Role of lipins in cardiovascular diseases.Lipids in health and disease · 2023
    Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cody D SmithEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Chien-Te LinEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Shawna L McMillinEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Luke A WeyrauchEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Cameron A SchmidtEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Cheryl A SmithEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Irwin J KurlandDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York.
Carol A WitczakEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.ORCID 0000-0003-4165-4740
P Darrell NeuferEast Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.ORCID 0000-0002-2256-6051
East Carolina University · USAlbert Einstein College of Medicine · US

Funding

Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Bioenergetics of Metformin Action and AgingR01AG069679 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NEUFER, P DARRELL · 2020 to 2024
$1.8M
Impact of organic cations on mitochondrial energetic driving forces and metabolic efficiencyR01DK110656 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2016 to 2019
$1.8M
Calmodulin Kinases and Control of Skeletal Muscle Glucose MetabolismR01DK103562 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI WITCZAK, CAROL ANN · 2015 to 2019
$1.7M
Redox Biology and Muscle Insulin SensitivityR01DK096907 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2012 to 2015
$1.4M
Tissue Specific Impact of Organic Cations on Mitochondrial Energy TransductionF32DK127632 · NIDDK · EAST CAROLINA UNIVERSITY · PI SCHMIDT, CAMERON ALAN · 2021 to 2022
$94k
Molecular Mechanisms Regulating Functional Overload Stimulated Glucose Uptake in Skeletal MuscleF31DK119080 · NIDDK · EAST CAROLINA UNIVERSITY · PI MCMILLIN, SHAWNA · 2018 to 2019
$66k
NIA NIH HHS R01 AG069679NIDDK NIH HHS F31 DK119080NIDDK NIH HHS F32 DK127632NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK096907NIDDK NIH HHS R01 DK103562NIDDK NIH HHS R01 DK110656
6 · The paper itself

Abstract

Elevated mitochondrial hydrogen peroxide (H

Indexed as

AnimalsCatalaseEnergy MetabolismGlucose IntoleranceMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicMitochondria, MuscleMuscle, SkeletalOrgan SpecificityOxidation-ReductionOxidative StressPPAR alphaCatalasePPAR alphafat oxidationglucose toleranceinsulin resistancemitochondriaskeletal muscle

Identifiers

PMID33813880
PMCPMC8238127
OpenAlexW3145458045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.