ArticleHypertension (Dallas, Tex. : 1979)2021
Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses.
Open access · hybridAbstract read
In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 6 pooled it
12.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Comparison of the health-related outcomes for traditional cigarettes, e-cigarettes, heat-not-burn cigarettes and snus: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Consultation-based interventions to optimize medication adherence in primary care: a systematic review.Family practice · 2026Pooled it
- European guidelines for hypertension in 2024: a comparison of key recommendations for clinical practice.Nature reviews. Cardiology · 2025Guideline
- Optimal Antihypertensive Systolic Blood Pressure: A Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2024Pooled it
- Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT.Communications biology · 2022Pooled it
- Efficacy and safety of intensive antihypertensive strategy in patients with low diastolic blood pressure: a secondary analysis of a cluster randomised trial.Heart (British Cardiac Society) · 2026Trial
- Trial
- A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.Nature medicine · 2026Article
- Association of combined waist-to-height ratio and systolic blood pressure categories with incident cardiovascular disease in middle-aged and older adults.Scientific reports · 2026Article
- Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Joint association of risk factor clustering and socioeconomic position with non-communicable disease mortality risk: a prospective cohort study of 576 299 Norwegian men and women in the NCDNOR project.BMJ public health · 2026Article
- Degree of hypertension and subclinical coronary atherosclerosis in asymptomatic individuals without cardiovascular disease.PloS one · 2026Article
- Associations of relative muscular strength with blood pressure changes and incident hypertension: a prospective cohort study in Korea.BMC public health · 2025Article
- Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation.Nature reviews. Cardiology · 2025Review
- Burden of High Systolic Blood Pressure in the Eastern Mediterranean Region, 1990 to 2021: Results From the Global Burden of Disease Study 2021.Journal of the American Heart Association · 2025Article
- Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian randomization approaches.Genome medicine · 2025Article
- Baseline Diastolic BP and BP-Lowering Effects on Cardiovascular Outcomes and All-Cause Mortality: A Meta-Analysis.Journal of the American Society of Nephrology : JASN · 2025Article
- A Mediterranean-Style Diet with Lean Beef Lowers Blood Pressure and Improves Vascular Function: Secondary Outcomes from a Randomized Crossover Trial.Current developments in nutrition · 2025Article
- Genetically predicted endogenous sex hormone levels with risk of eczema or dermatitis.Hormones (Athens, Greece) · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 10 institutions in 7 countries.
Rainer MalikInstitute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-University LMU, Munich, Germany (R.M., M.K.G., M.D.).
Marios K GeorgakisInstitute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-University LMU, Munich, Germany (R.M., M.K.G., M.D.).
Marijana VujkovicPerelman School of Medicine, University of Pennsylvania, Philadelphia (M.V., S.M.D.).
Scott M DamrauerPerelman School of Medicine, University of Pennsylvania, Philadelphia (M.V., S.M.D.).
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health (P.E., V.K., D.G.), Imperial College London, United Kingdom.
Ville KarhunenDepartment of Epidemiology and Biostatistics, School of Public Health (P.E., V.K., D.G.), Imperial College London, United Kingdom.
Alice GiontellaDepartment of Medicine, University of Verona, Italy (A.G., C.F.).
Cristiano FavaDepartment of Medicine, University of Verona, Italy (A.G., C.F.).
Jacklyn N HellwegeDivision of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center (J.N.H., M.M.S.) Vanderbilt University Medical Center, Nashville, TN.
Megan M ShueyDivision of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center (J.N.H., M.M.S.) Vanderbilt University Medical Center, Nashville, TN.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute (T.L.E.), Vanderbilt University Medical Center, Nashville, TN.
Tormod RogneDepartment of Circulation and Medical Imaging, Gemini Center for Sepsis Research, Norwegian University of Science and Technology, Trondheim, Norway (T.R.).
Bjørn O ÅsvoldDepartment of Endocrinology, Clinic of Medicine (B.O.Å.), St. Olav's Hospital, Trondheim University Hospital, Norway.
Ben M BrumptonClinic of Thoracic and Occupational Medicine (B.M.B.), St. Olav's Hospital, Trondheim University Hospital, Norway.
Stephen BurgessCardiovascular Epidemiology Unit, University of Cambridge, United Kingdom (S.B.).
Martin DichgansInstitute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-University LMU, Munich, Germany (R.M., M.K.G., M.D.).
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health (P.E., V.K., D.G.), Imperial College London, United Kingdom.
Norwegian University of Science and Technology · NOVanderbilt University Medical Center · USLudwig-Maximilians-Universität München · DEPhiladelphia VA Medical Center · USUniversity of Verona · ITGerman Center for Neurodegenerative Diseases · DEImperial College Healthcare NHS Trust · GBImperial College London · GBMRC Biostatistics Unit · GBSt George's, University of London · GB
Funding
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3MPrecision Cardio-Metabolic Phenotyping for Genetic Discovery and Risk PredictionIK2CX001780 · VA · PHILADELPHIA VA MEDICAL CENTER · PI DAMRAUER, SCOTT MICHAEL · 2018 to 2023
–British Heart Foundation CH/12/2/29428British Heart Foundation RE/18/4/34215British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946CSRD VA IK2 CX001780Medical Research Council MC_UU_00002/7Medical Research Council MR/S019669/1NICHD NIH HHS K12 HD043483Wellcome Trust 203928Wellcome Trust 204623
Abstract
[Figure: see text].
Indexed as
Blood PressureCardiovascular DiseasesFemaleHumansIncidenceMaleMendelian Randomization AnalysisMiddle Agedblood pressurecoronary artery diseasehypertensionprimary preventionstroke
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.