Evidence map›Paper›PMID 33813843›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Decreased 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice.

Ying Wang, Jian Wang, Rong Yang, Piwen Wang, Rene Porche, Samuel Kim, Kabirullah Lutfy, Limei Liu, Theodore C Friedman, Meisheng Jiang and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ying Wang *Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (Y.W., R.Y., Y.L.).
Jian Wang *Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Sciences, Los Angeles, CA (Y.W., J.W., P.W., R.P., S.K., K.L., T.C.F., Y.L.).
Rong Yang *Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (Y.W., R.Y., Y.L.).
Piwen WangDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Sciences, Los Angeles, CA (Y.W., J.W., P.W., R.P., S.K., K.L., T.C.F., Y.L.).
Rene PorcheDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Sciences, Los Angeles, CA (Y.W., J.W., P.W., R.P., S.K., K.L., T.C.F., Y.L.).
Samuel KimDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Sciences, Los Angeles, CA (Y.W., J.W., P.W., R.P., S.K., K.L., T.C.F., Y.L.).
Kabirullah LutfyDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Sciences, Los Angeles, CA (Y.W., J.W., P.W., R.P., S.K., K.L., T.C.F., Y.L.).
Limei LiuDepartment of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, China (L.L.).
Theodore C FriedmanDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Sciences, Los Angeles, CA (Y.W., J.W., P.W., R.P., S.K., K.L., T.C.F., Y.L.).
Meisheng JiangDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (M.J.).
Yanjun LiuDepartment of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (Y.W., R.Y., Y.L.).
Charles R. Drew University of Medicine and Science · USUniversity of California, Los Angeles · USShanghai Tenth People's Hospital · CNJilin University · CNShanghai Sixth People's Hospital · CN

Funding

Drew MIDARP (Infrastructure in Drug Abuse Research)R24DA017298 · NIDA · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI FRIEDMAN, THEODORE C · 2004 to 2018
$5.0M
The Role of Adipose H6PDH in Type 2 Diabetes and ObesitySC1DK104821 · NIDDK · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI LIU, YANJUN · 2014 to 2017
$1.3M
NIDA NIH HHS R24 DA017298NIDDK NIH HHS SC1 DK104821
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Smoking11-beta-Hydroxysteroid Dehydrogenase Type 2AnimalsBlood PressureEpithelial Sodium ChannelsKidneyMaleMiceMineralocorticoid Receptor AntagonistsNicotinePhosphorylationProto-Oncogene Proteins c-aktReceptors, MineralocorticoidSpironolactone11-beta-Hydroxysteroid Dehydrogenase Type 2Epithelial Sodium ChannelsMineralocorticoid Receptor AntagonistsNicotineProto-Oncogene Proteins c-aktReceptors, MineralocorticoidSpironolactoneAKTblood pressureCEBP-betaENaCmineralocorticoid receptornicotinespironolactone

Identifiers

PMID33813843
PMCPMC8119334
OpenAlexW3148703774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.