Evidence map›Paper›PMID 33813838›Full record

ArticleCirculation. Heart failure2021

Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support.

Edo Y Birati, Samer S Najjar, Ryan J Tedford, Brian A Houston, Supriya Shore, Esther Vorovich, Pavan Atluri, Kimberly Urgo, Maria Molina, Susan Chambers and 23 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 16 institutions in 4 countries.

Edo Y BiratiCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Samer S NajjarMedStar Washington Hospital Center, Washington, DC (S.S.N.).
Ryan J TedfordMedical University of South Carolina, Charleston, SC (R.J.T., B.A.H.).
Brian A HoustonMedical University of South Carolina, Charleston, SC (R.J.T., B.A.H.).
Supriya ShoreCardiovascular Division, University of Michigan, Ann Arbor (S.S.).
Esther VorovichDivision of Cardiology, Northwestern University, Chicago, IL (E.V.).
Pavan AtluriDepartment of Cardiothoracic Surgery (P.A.), University of Pennsylvania, Philadelphia.
Kimberly UrgoCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Maria MolinaCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Susan ChambersCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Nicole EscobarCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Eileen HsichHeart and Vascular Institute at the Cleveland Clinic and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, OH (E.H., J.D.E.).
Jerry D EstepHeart and Vascular Institute at the Cleveland Clinic and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, OH (E.H., J.D.E.).
Kevin M AlexanderDivision of Cardiovascular Medicine and the Stanford Cardiovascular Institute, Stanford University School of Medicine, CA (K.M.A., J.J.T.).
Jeffrey J TeutebergDivision of Cardiovascular Medicine and the Stanford Cardiovascular Institute, Stanford University School of Medicine, CA (K.M.A., J.J.T.).
Sunit-Preet ChaudhrySt Vincent Medical Group, St Vincent Heart Center, Indianapolis, IN (S.-P.C., A.R.).
Ashwin RavichandranSt Vincent Medical Group, St Vincent Heart Center, Indianapolis, IN (S.-P.C., A.R.).
Adam D DeVoreDuke Clinical Research Institute and Department of Medicine, Duke University School of Medicine, Durham, NC (A.D.D.).
Kenneth B MarguliesCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Thomas C HanffCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Ross ZimmerCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Arman KilicDivision of Cardiac Surgery, University of Pittsburgh Medical Center, PA (A.K.).
Joyce W WaldCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Himabindu VidulaDivision of Cardiology, University of Rochester School of Medicine and Dentistry, NY (H.V., J.M.).
John MartensDivision of Cardiology, University of Rochester School of Medicine and Dentistry, NY (H.V., J.M.).
Emily A BlumbergDivision of Infectious Diseases (E.A.B.), University of Pennsylvania, Philadelphia.
Jeremy A MazurekCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Anjali T OwensCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Lee R GoldbergCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Jesus Alvarez-GarciaZena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, NY (J.A.-G., D.M.M., N.M.).
Donna M ManciniZena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, NY (J.A.-G., D.M.M., N.M.).
Noah MossZena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, NY (J.A.-G., D.M.M., N.M.).
Michael V GenuardiCardiovascular Division, Department of Medicine (E.Y.B., K.U., M.M., S.C., N.E., K.B.M., T.C.H., R.Z., J.W.W., J.A.M., A.T.O., L.R.G., M.V.G.), University of Pennsylvania, Philadelphia.
Mahindra and Mahindra Limited (India) · INCardiovascular Institute of the South · USCleveland Clinic Lerner College of Medicine · USMACOM (United States) · USMedical University of South Carolina · USSt Vincent Hospital · USUniversity of Pennsylvania · USBar-Ilan University · ILDr. M.G.R. Educational and Research Institute · INDuke University · USMedStar Washington Hospital Center · USNorthwestern University · USTwitter (United States) · USUniversity of Michigan · USUniversity of Pittsburgh Medical Center · USUniversity of Rochester · US

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
Stanford Medicine Center for Longevity and Healthy Aging Research Education CoreP30AG059307 · NIA · STANFORD UNIVERSITY · PI PERIYAKOIL, VYJEYANTHI S, YESAVAGE, JEROME A · 2018 to 2025
$4.9M
NIA NIH HHS P30 AG059307
6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) pandemic continues to afflict millions of people worldwide. Patients with end-stage heart failure and left ventricular assist devices (LVADs) may be at risk for severe COVID-19 given a high prevalence of complex comorbidities and functional impaired immunity. The objective of this study is to describe the clinical characteristics and outcomes of COVID-19 in patients with end-stage heart failure and durable LVADs.

methodsThe Trans-CoV-VAD registry is a multi-center registry of LVAD and cardiac transplant patients in the United States with confirmed COVID-19. Patient characteristics, exposure history, presentation, laboratory data, course, and clinical outcomes were collected by participating institutions and reviewed by a central data repository. This report represents the participation of the first 9 centers to report LVAD data into the registry.

resultsA total of 40 patients were included in this cohort. The median age was 56 years (interquartile range, 46-68), 14 (35%) were women, and 21 (52%) were Black. Among the most common presenting symptoms were cough (41%), fever, and fatigue (both 38%). A total of 18% were asymptomatic at diagnosis. Only 43% of the patients reported either subjective or measured fever during the entire course of illness. Over half (60%) required hospitalization, and 8 patients (20%) died, often after lengthy hospitalizations.

conclusionsWe present the largest case series of LVAD patients with COVID-19 to date. Understanding these characteristics is essential in an effort to improve the outcome of this complex patient population.

Indexed as

Heart-Assist DevicesPandemicsAgedComorbidityCOVID-19FemaleHeart FailureHeart VentriclesHospitalizationHumansMaleMiddle AgedRegistriesSARS-CoV-2United StatesCOVID-19heart failurehospitalizationoutcomes researchSARS-CoV-2ventricular assist device

Identifiers

PMID33813838
PMCPMC8059761
OpenAlexW3149101843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.