Evidence map›Paper›PMID 33813707›Full record

ArticleEnvironmental science and pollution research international2021

Inflammatory injury and mitophagy of the brain in chicken exposed to Cr(VI).

Shuhua Guo, Xiaozhou Wang, Lumei Wang, Guodong Cheng, Meihua Zhang, Yuxiao Xing, Xiaona Zhao, Yongxia Liu, Jianzhu Liu

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Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shuhua Guo *College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, China.
Xiaozhou Wang *College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, China.
Lumei WangCollege of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, China.
Guodong ChengResearch Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai`an, 271018, Shandong, China.
Meihua ZhangCollege of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, China.
Yuxiao XingCollege of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, China.
Xiaona ZhaoCollege of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, China.
Yongxia LiuResearch Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai`an, 271018, Shandong, China. Liuuongxia@sdau.edu.cn.ORCID http://orcid.org/0000-0001-6125-8599
Jianzhu LiuCollege of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, China. Liujz@sdau.edu.cn.
Shandong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to determine whether Cr(VI) can induce inflammatory injury in chicken brain and influence mitophagy and related mechanisms. A total of 120 hyline brown chickens (1 day old, 20±3g) were selected and randomly divided into four groups and given different doses of Cr(VI) (0, 10, 30, and 50 mg/kg) every day at 45 days. Results showed that excessive intake of Cr(VI) led to increased tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) levels and decreased interferon-gamma (IF-γ) level. Cr(VI) increased the production of mitochondrial reactive oxygen species (ROS) in chicken brain cells, causing the decline of mitochondrial membrane potential (MMP) and formation of autophagosomes for mitophagy. In addition, Cr(VI) promoted the translocation of Parkin to the mitochondrial outer membrane, increased LC3-II protein level, and inhibited p62 and TOM20 protein expression. In conclusion, excessive Cr(VI) intake can induce inflammatory injury and mitophagy in chicken brain.

Indexed as

ChickensMitophagyAnimalsBrainChromiumRandom AllocationReactive Oxygen SpeciesChromiumchromium hexavalent ionReactive Oxygen SpeciesBrainChickensCr(VI)InflammatoryMitophagyParkin

Identifiers

PMID33813707
OpenAlexW3141953587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.