Evidence map›Paper›PMID 33813619›Full record

Observational studyClinical rheumatology2021

Evaluation of cardiac function and systolic dyssynchrony of fetuses exposed to maternal autoimmune diseases using speckle tracking echocardiography.

ShaSha Duan, Si Ha, ShuJuan Li, YaXi Wang, YiLu Shi, HaiYue Zhao, Lu Zhang, XiaoShan Zhang, Yong Wang

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

ShaSha DuanDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
Si HaDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
ShuJuan LiDepartment of Emergency, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
YaXi WangDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
YiLu ShiDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
HaiYue ZhaoDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
Lu ZhangDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
XiaoShan ZhangDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China. zhangxsh133@163.com.
Yong WangDepartment of Rheumatology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China. wyxjyxy@126.com.
Inner Mongolia Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CN

Funding

Major Project of Affiliated Hospital of Inner Mongolia Medical College NYFY ZD 2012012Natural Science Foundation of Inner Mongolia 2016MS(LH)0808Natural Science Foundation of Inner Mongolia 2019MS08148Science and Technology Million Project of Inner Mongolia Medical University YKD2020KJBW(LF)018Scientific Research Project of institution of higher education of Inner Mongolia NJZY21588the Science and Technology Planned Project of Inner Mongolia 2019GG081Youth Innovation Fund of Inner Mongolia Medical University YKD2018QNCX041
6 · The paper itself

Abstract

objectivesTo compare cardiac function and systolic dyssynchrony of fetuses not exposed to and those exposed to maternal autoimmune antibodies using two-dimensional speckle tracking echocardiography (2DSTE).

methodsAn observational study of 52 fetuses, 18 from mothers with autoimmune antibodies (anti-SSA/Ro60, anti-Ro52 or/and anti-SSB/La) and 34 from healthy mothers without antibodies, was conducted. Maternal baseline characteristics, fetoplacental Doppler parameters, and conventional echocardiographic data were prospectively collected. Systolic global and regional longitudinal strain of left and right ventricle (LV and RV) and the time to peak strain of regional myocardium were measured using 2DSTE. We also calculated the differences in time to peak strain between the LV free wall and RV free wall (two-chamber dyssynchrony, 2C-DYS) and the LV dyssynchrony between the septum and LV free wall (one-chamber dyssynchrony, 1C-DYS).

resultsThere were no significant differences in conventional systolic and diastolic functional parameters for the LV and RV. No effect modification was demonstrated in a myocardial deformation analysis. However, 1C-DYS was significantly more prolonged in the maternal autoimmune disease group (19.50 [8.00 to 29.25] vs. 28.50 [13.50 to 39.25], P = 0.042).

conclusionsLV systolic mechanical dyssynchrony in fetuses of mothers with autoimmune antibodies suggests in-utero subclinical damage of the cardiac conduction system. Key points • The left ventricular systolic dyssynchrony was significantly more prolonged in the maternal autoimmune disease (AD) fetuses. • Subclinical damage to the left ventricular conduction system of the fetal heart in maternal AD was observed. • Systolic and diastolic functional of the left and right ventricle were preserved in fetuses exposed to maternal autoimmune disease.

Indexed as

Autoimmune DiseasesVentricular Dysfunction, LeftDiastoleEchocardiographyFemaleFetusHumansPregnancySystoleAntibodiesAnti-SSAAnti-SSBEchocardiographySystolic dyssynchrony

Identifiers

PMID33813619
PMCPMC8357746
OpenAlexW3143612288

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.