Evidence map›Paper›PMID 33813307›Full record

ArticleJournal of inorganic biochemistry2021

A SARS-CoV-2 -human metalloproteome interaction map.

Christos T Chasapis, Athanasia K Georgiopoulou, Spyros P Perlepes, Geir Bjørklund, Massimiliano Peana

Open access · greenAbstract read
In one paragraph

Article in Journal of inorganic biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  6. Structural modeling of protein ensembles between E3 RING ligases and SARS-CoV-2: The role of zinc binding domains.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Article
  7. Review
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  9. The zinc proteome of SARS-CoV-2.Metallomics : integrated biometal science · 2022
    Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Christos T ChasapisNMR Facility, Instrumental Analysis Laboratory, School of Natural Sciences, University of Patras, Patras, Greece; Institute of Chemical Engineering Sciences, Foundation for Research and Technology, Hellas (FORTH/ICE-HT), Patras, Greece; School of Agricultural Science, University of Patras, Mesolonghi, Greece. Electronic address: cchasapis@upatras.gr.
Athanasia K GeorgiopoulouUniversity of Patras, Greece.
Spyros P PerlepesDepartment of Chemistry, University of Patras, Patras, Greece.
Geir BjørklundCouncil for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway.
Massimiliano PeanaDepartment of Chemistry and Pharmacy, University of Sassari, Sassari, Italy.
University of Patras · GRThe Research Council of Norway · NOUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent pandemic caused by the novel coronavirus resulted in the greatest global health crisis since the Spanish flu pandemic of 1918. There is limited knowledge of whether SARS-CoV-2 is physically associated with human metalloproteins. Recently, high-confidence, experimentally supported protein-protein interactions between SARS-CoV-2 and human proteins were reported. In this work, 58 metalloproteins among these human targets have been identified by a structure-based approach. This study reveals that most human metalloproteins interact with the recently discovered SARS-CoV-2 orf8 protein, whose antibodies are one of the principal markers of SARS-CoV-2 infections. Furthermore, this work provides sufficient evidence to conclude that Zn

Indexed as

Carrier ProteinsCOVID-19Host-Pathogen InteractionsHumansMetalloproteinsNervous System DiseasesSARS-CoV-2Viral ProteinsCarrier ProteinsMetalloproteinsORF8 protein, SARS-CoV-2Viral Proteinszinc-binding proteinMetal homeostasisMetalloproteomePPISARS-CoV-2SARS-CoV-2 orf8

Identifiers

PMID33813307
PMCPMC7955571
OpenAlexW3139322491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.