Evidence map›Paper›PMID 33813057›Full record

ArticleThe journal of pain2021

Specialized Pro-resolving Mediators Reduce Pro-nociceptive Inflammatory Mediator Production in Models of Localized Provoked Vulvodynia.

Megan L Falsetta, Ronald W Wood, Mitchell A Linder, Adrienne D Bonham, Kenneth V Honn, Krishna Rao Maddipati, Richard P Phipps, Constantine G Haidaris, David C Foster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Inflammation, lipids, and pain in vulvar disease.Pharmacology & therapeutics · 2023
    Review
  14. Review
  15. Immune mechanisms in vulvodynia: key roles for mast cells and fibroblasts.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Megan L FalsettaDepartment of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry Rochester, New York; Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York. Electronic address: megan_falsetta@urmc.rochester.edu.
Ronald W WoodDepartment of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry Rochester, New York.
Mitchell A LinderDepartment of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry Rochester, New York.
Adrienne D BonhamDepartment of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry Rochester, New York.
Kenneth V HonnDepartment of Pathology, Wayne State University, School of Medicine, Detroit, Michigan.
Krishna Rao MaddipatiDepartment of Pathology, Wayne State University, School of Medicine, Detroit, Michigan.
Richard P PhippsIndependent Scholar, Rochester, New York.
Constantine G HaidarisDepartment of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry Rochester, New York.
David C FosterDepartment of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry Rochester, New York.

Funding

Mechanisms of vulvodynia involving dysregulation of pro-resolving lipidsR01HD092334 · NICHD · UNIVERSITY OF ROCHESTER · PI HAIDARIS, CONSTANTINE G, WOOD, MEGAN LINDSAY FALSETTA · 2018 to 2022
$2.4M
Localized Vulvodynia Pathogenesis: Fibroblast, Yeast, and MelanocortinR01HD069313 · NICHD · UNIVERSITY OF ROCHESTER · PI FOSTER, DAVID CHARLES, HAIDARIS, CONSTANTINE G · 2012 to 2016
$1.5M
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425k
NCRR NIH HHS S10 RR027926NICHD NIH HHS R01 HD069313NICHD NIH HHS R01 HD092334
6 · The paper itself

Abstract

Localized provoked vulvodynia (LPV) is the most common cause of chronic dyspareunia in premenopausal women, characterized by pain with light touch to the vulvar vestibule surrounding the vaginal opening. The devastating impact of LPV includes sexual dysfunction, infertility, depression, and even suicide. Yet, its etiology is unclear. No effective medical therapy exists; surgical removal of the painful vestibule is the last resort. In LPV, the vestibule expresses a unique inflammatory profile with elevated levels of pro-nociceptive proinflammatory mediators prostaglandin E

Indexed as

DinoprostoneInterleukin-6AnimalsDisease Models, AnimalDocosahexaenoic AcidsFemaleFibroblastsInflammationMiceNociceptionVulvodynia7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidDinoprostoneDocosahexaenoic AcidsInterleukin-6interleukin-6, mouseinflammationpainpolyunsaturated fatty acidsSpecialized pro-resolving mediatorsvulvodynia

Identifiers

PMID33813057
PMCPMC8484336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.