Evidence map›Paper›PMID 33812914›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

Rapid 4D-MRI reconstruction using a deep radial convolutional neural network: Dracula.

Joshua N Freedman, Oliver J Gurney-Champion, Simeon Nill, Anna-Maria Shiarli, Hannah E Bainbridge, Henry C Mandeville, Dow-Mu Koh, Fiona McDonald, Marc Kachelrieß, Uwe Oelfke and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 4 countries.

Joshua N FreedmanJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Joshua.Freedman@elekta.com.
Oliver J Gurney-ChampionJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, The Netherlands. Electronic address: o.j.gurney-champion@amsterdamumc.nl.
Simeon NillJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Simeon.Nill@icr.ac.uk.
Anna-Maria ShiarliDepartment of Radiotherapy, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: a.shiarli@nhs.net.
Hannah E BainbridgeDepartment of Radiotherapy, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom; Department of Radiotherapy, Portsmouth Hospitals University NHS Trust, Queen Alexandra Hospital, United Kingdom. Electronic address: hannah.bainbridge@porthosp.nhs.uk.
Henry C MandevilleDepartment of Radiotherapy, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Henry.Mandeville@rmh.nhs.uk.
Dow-Mu KohDepartment of Radiology, The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Dow-Mu.Koh@icr.ac.uk.
Fiona McDonaldDepartment of Radiotherapy, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Fiona.McDonald@rmh.nhs.uk.
Marc KachelrießDivision of X-Ray Imaging and CT, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: marc.kachelriess@dkfz.de.
Uwe OelfkeJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: uwe.oelfke@icr.ac.uk.
Andreas WetscherekJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Andreas.Wetscherek@icr.ac.uk.
Royal Marsden NHS Foundation Trust · GBGerman Cancer Research Center · DE

Funding

Cancer Research UK 19727Cancer Research UK 28284
6 · The paper itself

Abstract

background and purpose4D and midposition MRI could inform plan adaptation in lung and abdominal MR-guided radiotherapy. We present deep learning-based solutions to overcome long 4D-MRI reconstruction times while maintaining high image quality and short scan times.

methodsTwo 3D U-net deep convolutional neural networks were trained to accelerate the 4D joint MoCo-HDTV reconstruction. For the first network, gridded and joint MoCo-HDTV-reconstructed 4D-MRI were used as input and target data, respectively, whereas the second network was trained to directly calculate the midposition image. For both networks, input and target data had dimensions of 256 × 256 voxels (2D) and 16 respiratory phases. Deep learning-based MRI were verified against joint MoCo-HDTV-reconstructed MRI using the structural similarity index (SSIM) and the naturalness image quality evaluator (NIQE). Moreover, two experienced observers contoured the gross tumour volume and scored the images in a blinded study.

resultsFor 12 subjects, previously unseen by the networks, high-quality 4D and midposition MRI (1.25 × 1.25 × 3.3 mm

conclusionOur results suggest that the joint MoCo-HDTV and midposition algorithms can each be approximated by a deep convolutional neural network. This rapid reconstruction of 4D and midposition MRI facilitates online treatment adaptation in thoracic or abdominal MR-guided radiotherapy.

Indexed as

Imaging, Three-DimensionalLung NeoplasmsAlgorithmsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeural Networks, Computer4D MRIDeep convolutional neural networksMagnetic resonance guided radiotherapyMR-LinacRadiotherapy treatment planning

Identifiers

PMID33812914
PMCPMC8216429
OpenAlexW3151039536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.