Evidence map›Paper›PMID 33812874›Full record

Observational studyEnvironmental research2021

Semen quality and windows of susceptibility: A case study during COVID-19 outbreak in China.

Tingting Yang, Li Deng, Boyu Sun, Shifu Zhang, Yang Xian, Xiao Xiao, Yu Zhan, Kehui Xu, Johnathan J Buonocore, Ya Tang and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Impact of Heavy Metals on Human Male Fertility-An Overview.Antioxidants (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tingting YangDepartment of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, PR China.
Li DengDepartment of Environmental Sciences and Engineering, College of Architecture and Environment, Sichuan University, PR China.
Boyu SunWuyuzhang Honors College, Sichuan University, Chengdu, PR China.
Shifu ZhangDepartment of Environmental Sciences and Engineering, College of Architecture and Environment, Sichuan University, PR China.
Yang XianDepartment of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, PR China.
Xiao XiaoDepartment of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, PR China.
Yu ZhanDepartment of Environmental Sciences and Engineering, College of Architecture and Environment, Sichuan University, PR China.
Kehui XuKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, PR China; Department of Reproductive Endocrinology, West China Second University Hospital, Sichuan University, Chengdu, China.
Johnathan J BuonocoreCenter for Climate, Health, and the Global Environment, Harvard T.H. Chan School of Public Health, USA.
Ya TangDepartment of Environmental Sciences and Engineering, College of Architecture and Environment, Sichuan University, PR China.
Fuping LiDepartment of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, PR China. Electronic address: lfpsnake@scu.edu.cn.
Yang QiuDepartment of Environmental Sciences and Engineering, College of Architecture and Environment, Sichuan University, PR China. Electronic address: yqiu@scu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the impact of air pollution exposure on semen quality parameters during COVID-19 outbreak in China, and to identify potential windows of susceptibility for semen quality.

methodsA retrospective observational study was carried out on 1991 semen samples collected between November 23, 2019 and July 23, 2020 (a period covering COVID-19 lock-down in China) from 781 sperm donor candidates at University-affiliated Sichuan Provincial Human Sperm Bank. Multivariate mixed-effects regression models were constructed to investigate the relationship between pollution exposure, windows of susceptibility, and semen quality, while controlling for biographic and meteorologic confounders. RESULT(S): The results indicated multiple windows of susceptibility for semen quality, especially sperm motility, due to ambient pollution exposure. Exposure to particulate matters (PM CONCLUSION(S): Potential windows of susceptibility for semen quality varied depending on air pollutants. Sperm motility was sensitive to pollution exposure. Findings from current study further elucidate the importance of sensitive periods during spermatogenesis and provide new evidence for the determinants of male fertility.

Indexed as

Air PollutantsAir PollutionCOVID-19ChinaCommunicable Disease ControlDisease OutbreaksHumansMaleParticulate MatterSARS-CoV-2Semen AnalysisSperm MotilityAir PollutantsParticulate MatterComputer sperm analysisPollution exposureSemen qualitySperm motilityWindows of susceptibility

Identifiers

PMID33812874
PMCPMC8542995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.