ArticleHuman immunology2021
How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans.
Article in Human immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- HLA alleles and dengue susceptibility across populations in the era of climate change: a comprehensive review.Frontiers in immunology · 2025Pooled it
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- PyPop: a mature open-source software pipeline for population genomics.Frontiers in immunology · 2024Article
- Human genetic determinants of COVID-19 in Brazil: challenges and future plans.Genetics and molecular biology · 2024Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- An HLA map of the world: A comparison of HLA frequencies in 200 worldwide populations reveals diverse patterns for class I and class II.Frontiers in genetics · 2023Article
- How HLA diversity is apportioned: influence of selection and relevance to transplantation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 9 countries.
Funding
Abstract
The Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affects population differentiation at these loci. In the present study we investigate genetic differentiation at HLA genes by comparing differentiation at microsatellites distributed genomewide to those in the MHC region. Our study uses a sample of 494 individuals from 30 human populations, 28 of which are Native Americans, all of whom were typed for genomewide and MHC region microsatellites. We find greater differentiation in the MHC than in the remainder of the genome (F
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