ArticleMedicina intensiva2021
Predictive factors of six-week mortality in critically ill patients with SARS-CoV-2: A multicenter prospective study.
Article in Medicina intensiva, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Predictive factors of mortality in patients admitted to the emergency department for SARS-Cov2 pneumonia.La Tunisie medicale · 2024Observational
- Assessing the impact of vaccines on COVID-19 efficacy in survival rates: a survival analysis approach for clinical decision support.Frontiers in public health · 2024Article
- Artificial-Intelligence-Driven Algorithms for Predicting Response to Corticosteroid Treatment in Patients with Post-Acute COVID-19.Diagnostics (Basel, Switzerland) · 2023Article
- A differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients.Medicina intensiva · 2023Article
- Myocardial injury as a prognostic factor in critically ill patients with severe SARS-Cov-2 pneumonia.Medicina intensiva · 2023Article
- Association of vasopressors with mortality in critically ill patients with COVID-19: a systematic review and meta-analysis.Anesthesiology and perioperative science · 2023Review
- Impact of COVID-19 in nutritional and functional status of survivors admitted in intensive care units during the first outbreak. Preliminary results of the NUTRICOVID study.Clinical nutrition (Edinburgh, Scotland) · 2022Observational
- Impact of one year of pandemic on Spanish Intensive Care Units.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Article
- SARS-CoV-2 and COVID-19: A Narrative Review.British journal of biomedical science · 2022Review
- ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome.Journal of clinical medicine · 2021Article
- Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study.Journal of personalized medicine · 2021Article
- Barotrauma, invasive ventilation, and timing of tocilizumab as predictors of mortality along with inflammatory markers and comorbidities in critically ill COVID-19 patients: A retrospective study.Indian journal of anaesthesia · 2021Article
- Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19.Frontiers in immunology · 2021Observational
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42 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of the study is to identify the risk factors associated with mortality at six weeks, especially by analyzing the role of antivirals and munomodulators.
designProspective descriptive multicenter cohort study.
setting26 Intensive care units (ICU) from Andalusian region in Spain. PATIENTS OR
participantsConsecutive critically ill patients with confirmed SARS-CoV-2 infection were included from March 8 to May 30.
interventionsNone. VARIABLES: Variables analyzed were demographic, severity scores and clinical condition. Support therapy, drug and mortality were analyzed. An univariate followed by multivariate Cox regression with propensity score analysis was applied.
results495 patients were enrolled, but 73 of them were excluded for incomplete data. Thus, 422 patients were included in the final analysis. Median age was 63 years and 305 (72.3%) were men. ICU mortality: 144/422 34%; 14 days mortality: 81/422 (19.2%); 28 days mortality: 121/422 (28.7%); 6-week mortality 152/422 36.5%. By multivariable Cox proportional analysis, factors independently associated with 42-day mortality were age, APACHE II score, SOFA score at ICU admission >6, Lactate dehydrogenase at ICU admission >470U/L, Use of vasopressors, extrarenal depuration, %lymphocytes 72h post-ICU admission <6.5%, and thrombocytopenia whereas the use of lopinavir/ritonavir was a protective factor.
conclusionAge, APACHE II, SOFA>value of 6 points, along with vasopressor requirements or renal replacement therapy have been identified as predictor factors of mortality at six weeks. Administration of corticosteroids showed no benefits in mortality, as did treatment with tocilizumab. Lopinavir/ritonavir administration is identified as a protective factor.
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