ArticleSICOT-J2021
Personalized alignment in total knee arthroplasty: current concepts.
Article in SICOT-J, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06507046 (Robotic Assisted Surgery Comparing Personalized Alignment Versus Mechanical Alignment of Total Knee Arthroplasty - A Randomized Controlled Trial), which is not on this map. Cited by 118 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Robotic Assisted Surgery Comparing Personalized Alignment Versus Mechanical Alignment of Total Knee Arthroplasty - A Randomized Controlled Trial
Who cites it
118 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Functional alignment in robotic-assisted total knee arthroplasty: a systematic review.Archives of orthopaedic and trauma surgery · 2024Pooled it
- The evolution of robotic systems for total knee arthroplasty, each system must be assessed for its own value: a systematic review of clinical evidence and meta-analysis.Archives of orthopaedic and trauma surgery · 2023Pooled it
- EPMEDBOT robotic-assisted total knee arthroplasty amplifies the advantage of intraoperative dynamic gap balance and alignment monitoring - a prospective randomized controlled and single center study.Journal of orthopaedic surgery and research · 2025Trial
- Medial expected gap (mEG): a quantitative, biology-guided predictor of coronal plane correction and knee balance in robotic functionally aligned total knee arthroplasty.Journal of robotic surgery · 2026Article
- Reduced postoperative inflammation and blood loss after robotic arm-assisted unicompartmental compared with total knee arthroplasty: A propensity score-matched analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Asia-Pacific expert consensus on robotic-assisted hip and knee arthroplasty.Arthroplasty (London, England) · 2026Review
- Preoperative gap phenotypes in functionally aligned robotic total knee arthroplasty: derivation and internal coherence of a driver-based classification.Journal of robotic surgery · 2026Article
- The three-pillar concept for functional knee positioning in robotic total knee arthroplasty.Journal of experimental orthopaedics · 2026Review
- Robot-Assisted TKA for Varus Knees: Post Hoc Exploratory Analysis of Alignment Strategy and Deformity Severity.Journal of clinical medicine · 2026Article
- Gait analysis after TKA: Do different alignment strategies lead to different outcomes? A systematic review.Musculoskeletal surgery · 2026Review
- Total knee arthroplasty alignment strategies and their impact on ankle and hindfoot: a systematic review.Musculoskeletal surgery · 2026Review
- Radiographic Accuracy and Consistency of Implant Placement Using the ROSALife (Basel, Switzerland) · 2026Article
- A minimal-incision and minimal-soft-tissue-injury (MISI) technique for robot-assisted total knee arthroplasty: a preliminary report.Journal of orthopaedic surgery and research · 2026Article
- Robotic arm-assisted total knee arthroplasty reduces postoperative inflammatory response and blood loss compared to manual total knee arthroplasty: A matched-pairs analysis of 688 patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Robotic-assisted total knee arthroplasty reduces alignment variability and rotational outliers compared with conventional techniques.International orthopaedics · 2026Article
- Posterior Tibial Plateau Offset Is Reduced During Total Knee Arthroplasty and Is Associated with Tibial Component Malpositioning.Medical sciences (Basel, Switzerland) · 2026Article
- Alignment and/or ligament balancing? Towards truly personalized total knee arthroplasty-A narrative review.Journal of experimental orthopaedics · 2026Review
- Increasing research on personalized alignment concepts, robotic-assisted surgery and artificial intelligence in total knee arthroplasty: A bibliometric analysis of the last 10 years inJournal of experimental orthopaedics · 2026Review
- Biomechanical analysis of surgical alignment and design in total knee arthroplasty.Archives of orthopaedic and trauma surgery · 2026Article
- Lateral deviation of the prosthetic trochlear angle relative to the quadriceps vector in mechanically aligned total knee arthroplasty: a radiological and clinical analysis.BMC musculoskeletal disorders · 2026Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally in total knee arthroplasty (TKA), a post-operative neutral alignment was the gold standard. This principle has been contested as functional outcomes were found to be inconsistent. Analysis of limb alignment in the non-osteoarthritic population reveals variations from neutral alignment and consideration of a personalized or patient-specific alignment in TKA is challenging previous concepts. The aim of this review was to clarify the variations of current personalized alignments and to report their results. Current personalized approaches of alignment reported are: kinematic, inverse kinematic, restricted kinematic, and functional. The principle of "kinematic alignment" is knee resurfacing with restitution of pre-arthritic anatomy. The aim is to resurface the femur maintaining the native femoral joint line obliquity. The flexion and extension gaps are balanced with the tibial resection. The principle of the "inverse kinematic alignment" is to resurface the tibia with similar medial and lateral bone resections in order to keep the native tibial joint line obliquity. Gap balancing is performed by adjusting the femoral resections. To avoid reproducing extreme anatomical alignments there is "restricted kinematic alignment" which is a compromise between mechanical alignment and true kinematic alignment with a defined safe zone of alignment. Finally, there is the concept of "functional alignment" which is an evolution of kinematic alignment as enabling technology has progressed. This is obtained by manipulating alignment, bone resections, soft tissue releases, and/or implant positioning with a robotic-assisted system to optimize TKA function for a patient's specific alignment, bone morphology, and soft tissue envelope. The aim of personalizing alignment is to restore native knee kinematics and improve functional outcomes after TKA. A long-term follow-up remains crucial to assess both outcomes and implant survivorship of these current concepts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.