Evidence map›Paper›PMID 33811957›Full record

ReviewPharmacology & therapeutics2021

Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms.

Kai Huang, Pan Zhang, Zhenghao Zhang, Ji Youn Youn, Chen Wang, Hongchun Zhang, Hua Cai

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacology & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 12 pooled it
109.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 12 syntheses or guidelines pooled it, 549 citations in OpenAlex.

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215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kai HuangDepartment of Anesthesiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States of America.
Pan ZhangCenter of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Zhenghao ZhangCenter of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Ji Youn YounDepartment of Anesthesiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States of America.
Chen WangCenter of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China. Electronic address: wangchen66366@163.com.
Hongchun ZhangCenter of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. Electronic address: 13701226664@139.com.
Hua CaiDepartment of Anesthesiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States of America. Electronic address: hcai@mednet.ucla.edu.
China-Japan Friendship Hospital · CNUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 has remained an uncontained, worldwide pandemic. While battling for the disease in China, six Traditional Chinese Medicine (TCM) recipes have been shown to be remarkably effective for treating patients with COVID-19. The present review discusses principles of TCM in curing infectious disease, and clinical evidence and mechanisms of the 6 most effective TCM recipes used in treating COVID-19 in 92% of all of the confirmed cases in China. Applications of TCM and specific recipes in the treatment of other viral infections, such as those caused by SARS-CoV, MERS-CoV, hepatitis B virus, hepatitis C virus, influenza A virus (including H1N1 and H7N9), influenza B, dengue virus as well as Ebola virus, are also discussed. Among the 6 TCM recipes, Jinhua Qinggan (JHQG) granules and Lianhua Qingwen (LHQW) capsules are recommended during medical observation; Lung Cleansing and Detoxifying Decoction (LCDD) is recommended for the treatment of both severe and non-severe patients; Xuanfeibaidu (XFBD) granules are recommended for treating moderate cases; while Huashibaidu (HSBD) and Xuebijing (XBJ) have been used in managing severe cases effectively. The common components and the active ingredients of the six TCM recipes have been summarized to reveal most promising drug candidates. The potential molecular mechanisms of the active ingredients in the six TCM recipes that target ACE2, 3CL

Indexed as

COVID-19 Drug TreatmentHumansMedicine, Chinese TraditionalSARS-CoV-2Virus DiseasesAngiotensin converting enzyme 2 (ACE2)Coronavirus 3-chymotrypsin-like protease (3CL(pro))COVID-19Huashibaidu granules (HSBD)Interleukin-6 (IL-6)Jinhua Qinggan granules (JHQG)Lianhua Qingwen capsules (LHQW)Lung Cleansing and Detoxifying Decoction (LCDD)Traditional Chinese Medicine (TCM)Viral infectionsXuanfeibaidu granules (XFBD)Xuebijing (XBJ)

Identifiers

PMID33811957
PMCPMC8011334
OpenAlexW3143036104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.