Evidence map›Paper›PMID 33811919›Full record

ArticleJournal of molecular biology2021

Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions.

Colleen Kelly, Nicola Pace, Matthew Gage, Mark Pfuhl

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Regulation of Poly-E Motif Flexibility by pH, CaInternational journal of molecular sciences · 2022
    Article
  7. Article
  8. Review
  9. Titin N2A Domain and Its Interactions at the Sarcomere.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Colleen KellyDepartment of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA; UMass Movement Center, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Nicola PaceSchool of Cardiovascular Medicine and Sciences and Randall Centre, King's College London, Guy's Campus, London SE1 1UL, UK.
Matthew GageDepartment of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA; UMass Movement Center, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Mark PfuhlSchool of Cardiovascular Medicine and Sciences and Randall Centre, King's College London, Guy's Campus, London SE1 1UL, UK. Electronic address: mark.pfuhl@kcl.ac.uk.
King's College London · GBUniversity of Massachusetts Lowell · US

Funding

Exploring the role of pH in protein conformational change and muscle elasticityR15GM132840 · NIGMS · UNIVERSITY OF MASSACHUSETTS LOWELL · PI GAGE, MATTHEW J · 2019 to 2019
$457k
British Heart Foundation PG/15/22/31360Medical Research Council MC_U117533887NIGMS NIH HHS R15 GM132840
6 · The paper itself

Abstract

Titin, the largest single chain protein known so far, has long been known to play a critical role in passive muscle function but recent studies have highlighted titin's role in active muscle function. One of the key elements in this role is the Ca

Indexed as

Magnetic Resonance SpectroscopyAmino Acid SequenceAnimalsIonsMetalsMiceMutationPhosphorylationProtein DenaturationProtein DomainsProtein KinasesReproducibility of ResultsSolutionsStructural Homology, ProteinThermodynamicsIonsMetalsProtein KinasesSolutionstitin protein, mousecardiomyopathycontractionmuscleprotein dynamicsprotein stability

Identifiers

PMID33811919
PMCPMC9550216
OpenAlexW3149799717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.