ArticleThoracic cancer2021
Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma.
Article in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies.World journal of clinical oncology · 2026Review
- Perineural invasion as a prognostic factor and the efficacy of upfront surgery for low-risk cT2/T3N0M0 esophageal squamous cell carcinoma patients.Journal of thoracic disease · 2025Article
- Impact of perineural invasion in thoracic esophageal squamous cell carcinoma-a retrospective study with long-term follow-up outcomes.Journal of thoracic disease · 2025Article
- The impact of perineural invasion on prognosis in esophageal cancer patients after surgery: a systematic review and meta-analysis.Frontiers in oncology · 2025Review
- Computed tomography-based radiomics nomogram for prediction of lympho-vascular and perineural invasion in esophageal squamous cell cancer patients: a retrospective cohort study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Molecular and immunological characteristics of postoperative relapse in lymph node-positive esophageal squamous cell cancer.Cancer medicine · 2024Article
- Machine learning‑based prediction of survival prognosis in esophageal squamous cell carcinoma.Scientific reports · 2023Article
- Article
- Patterns and prognostic predictive value of perineural invasion in esophageal squamous cell carcinoma.BMC cancer · 2022Article
- Article
- Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma.Thoracic cancer · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough perineural invasion is a well known prognostic factor used in several cancers, its prognostic role in esophageal squamous cell carcinoma remains controversial. Here, we investigated the prognostic role of perineural invasion in surgically treated esophageal squamous cell carcinoma.
methodsWe retrospectively reviewed the medical records of 316 patients who underwent esophagectomy and lymph node dissection for esophageal squamous cell carcinoma between 2007 and 2016.
resultsOverall, 287 men (mean age: 62.73 ± 7.97 years) were included in the study. The median follow-up period was 35.97 ± 30.99 months, perineural invasion was confirmed in 25 patients, and three-year overall and disease-free survival were significantly lower in the perineural invasion group than in the no-perineural invasion group (75.9% vs. 40.0%, p < 0.001; 70.3% vs. 21.6%, p < 0.001). Cumulative incidences of locoregional recurrence and distant metastasis over three years were higher in the perineural invasion group (13.8% vs. 9.6%, p = 0.009 and 52.8% vs. 14.6%, p < 0.001). On performing multivariable analysis, perineural invasion, pathological stage, incomplete resection, and neoadjuvant therapy were adverse risk factors for disease-free survival. The concordance index increased when perineural invasion was included in the model (0.712 vs. 0.723). On subgroup analysis, perineural invasion demonstrated a prognostic value in node-negative patients (79.4% vs. 35.7%, p = 0.012).
conclusionsPerineural invasion was found to be an adverse risk factor for disease-free survival in surgically treated patients with esophageal squamous cell carcinoma. Close observation and individualized adjuvant therapy may be helpful for patients with perineural invasion.
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