Observational studyPaediatric anaesthesia2021
The performance of the heart rate variability-derived Newborn Infant Parasympathetic Evaluation Index as a measure of early postoperative pain and discomfort in infants-A prospective observational study.
Observational study in Paediatric anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Modified Pacifier on Pain, Physiological Variables, and Stress Level in Children Connected to Mechanical Ventilators During Vascular Opening
The Effect of Modified Teat on Pain, Physiological Variables, and Stress Level During Heel Blood Collection in Mechanically Ventilated Term Newborns
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Use of the NIPE monitor to continuously assess the nociception-comfort balance in mechanically ventilated, sedated, preterm infants: An observational study.European journal of pediatrics · 2026Observational
- Methods of Assessing Postoperative Pain in Infants (0-12 Months): A Scoping Review.Paediatric & neonatal pain · 2026Review
- Future perspectives of heart rate and oxygenation monitoring in the neonatal intensive care unit - a narrative review.Journal of clinical monitoring and computing · 2025Review
- Application of snake model imaging selection and analysis to the ultrasound diagnosis of white matter damage in preterm infants.BMC medical imaging · 2025Article
- The role of the sympathetic component of the autonomic nervous system on pain before and after third molar extraction- an observational cohort study.BMC anesthesiology · 2025Observational
- Does heart rate variability using the Newborn Infant Parasympathetic Evaluation index identify postsurgical pain levels and emergence delirium in toddlers? A prospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Observational
- Association between emergence delirium and brain status parameters in children undergoing general anesthesia: A prospective observational study.Paediatric anaesthesia · 2024Observational
- Biomarkers for assessing pain and pain relief in the neonatal intensive care unit.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Dexmedetomidine: An Alternative to Pain Treatment in Neonatology.Children (Basel, Switzerland) · 2023Review
- Evaluation of Nociception during Pediatric Surgery: A Topical Review.Journal of personalized medicine · 2023Review
- Usefulness of two types of pain monitors in newborns treated in NICU, in the opinion of experts: Results of the survey.Journal of mother and child · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe heart rate variability-derived Newborn Infant Parasympathetic Evaluation (NIPE™) Index is a continuous noninvasive tool for the assessment of pain and discomfort in infants. Little is known about its performance in the early postoperative setting, where assessment of pain/discomfort is usually based on discontinuous observational scoring systems or personal experience of medical staff.
aimsTo investigate the performance of the NIPE as a measure of early postoperative pain and/or discomfort in infants.
methodsThe potential of the NIPE to detect pain/discomfort, as assessed by two clinical scoring systems (FLACC and COMFORT-B scale), was investigated in postoperative infants (0-2 years).
resultsReceiver operating curve (ROC) analyses investigating the power of the NIPE to distinguish between comfort and pain/discomfort, revealed areas under the curve (AUC) of 0.77 for the FLACC, 0.81 for the COMFORT-B score, and 0.77 for a combination of FLACC & COMFORT-B. Logistic regression analysis provided initial evidence that the NIPE is an independent predictor of a FLACC score ≥4 and/or a COMFORT-B score ≥17, though R
conclusionsThe NIPE detected pain and discomfort in infants after general anesthesia with reasonable areas under the ROC curve (±0.8), whereas it was not predictive of clinically detectable pain or discomfort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.