Evidence map›Paper›PMID 33811702›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

ATR prevents Ca

Zhengke Li, Hui Wang-Heaton, Brian M Cartwright, Yetunde Makinwa, Benjamin A Hilton, Phillip R Musich, Nikolozi Shkriabai, Mamuka Kvaratskhelia, Shengheng Guan, Qian Chen and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

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  8. ATR prevents CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Zhengke LiDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Hui Wang-HeatonDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Brian M CartwrightDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Yetunde MakinwaDepartment of Cancer Biology, University of Toledo College of Medicine, Toledo, OH, USA.
Benjamin A HiltonDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Phillip R MusichDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Nikolozi ShkriabaiDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Mamuka KvaratskheliaDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Shengheng GuanDepartment of Pharmaceutical Chemistry and Mass Spectrometry Facility, University of California, San Francisco, CA, USA.
Qian ChenDepartment of Cancer Genetics and Epigenetics, City of Hope, Duarte, CA, USA.
Xiaochun YuDepartment of Cancer Genetics and Epigenetics, City of Hope, Duarte, CA, USA.
Yue ZouDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
East Tennessee State University · USUniversity of Colorado Denver · USCancer Genetics (United States) · USCity Of Hope National Medical Center · USUniversity of California, San Francisco · USUniversity of Toledo · US

Funding

RECOGNITION AND REPAIR OF UV DAMAGE TO HUMAN DNAR01CA086927 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ZOU, YUE · 2000 to 2011
$2.2M
ATR Isomerization in Cellular Responses to UV Damage of DNAR01CA219342 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI ZOU, YUE · 2017 to 2022
$1.8M
Antiapoptotic Role of Ataxia Telangiectasia and Rad3-RelatedR15GM112168 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI ZOU, YUE · 2014 to 2016
$422k
NCI NIH HHS R01 CA086927NCI NIH HHS R01 CA219342NIGMS NIH HHS R15 GM112168
6 · The paper itself

Abstract

Hyperactivation of PARP1 is known to be a major cause of necrotic cell death by depleting NAD

Indexed as

DNA DamageNecrosisApoptosisAtaxia Telangiectasia Mutated ProteinsCalciumHumansNeuroblastomaOxidative StressPhosphorylationPoly (ADP-Ribose) Polymerase-1Reactive Oxygen SpeciesSignal TransductionTumor Cells, CulturedAtaxia Telangiectasia Mutated ProteinsATR protein, humanCalciumPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Reactive Oxygen SpeciesATRCa2+ overloadnecrosisPARP1PARP1 phosphorylation

Identifiers

PMID33811702
PMCPMC8252533
OpenAlexW3147648981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.