Evidence map›Paper›PMID 33811694›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Neurotensin differentially regulates bile acid metabolism and intestinal FXR-bile acid transporter axis in response to nutrient abundance.

Jing Li, Jun Song, Baoxiang Yan, Heidi L Weiss, L Todd Weiss, Tianyan Gao, B Mark Evers

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Intestinal Enteroendocrine Cells: Present and Future Druggable Targets.International journal of molecular sciences · 2023
    Review
  7. Article
  8. New Insights in the Control of Fat Homeostasis: The Role of Neurotensin.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jing LiDepartment of Surgery, University of Kentucky, Lexington, KY, USA.
Jun SongDepartment of Surgery, University of Kentucky, Lexington, KY, USA.
Baoxiang YanMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Heidi L WeissMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
L Todd WeissMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Tianyan GaoMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
B Mark EversDepartment of Surgery, University of Kentucky, Lexington, KY, USA.
University of Kentucky · USMarkey Cancer Center · US

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8M
University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
SURGICAL STUDIES OF FUNCTIONAL GENE EXPRESSIONR01DK048498 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI EVERS, BERNARD MARK · 1996 to 2023
$7.9M
The Role of PHLPP in Colon CancerR01CA133429 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GAO, TIANYAN · 2009 to 2024
$5.6M
Mechanisms Regulating Neurotensin Secretion and FunctionR01DK112034 · NIDDK · UNIVERSITY OF KENTUCKY · PI EVERS, BERNARD MARK · 2017 to 2025
$4.9M
Altered Lipid Metabolism as a Novel Target for Colon Cancer TreatmentR01CA208343 · NCI · UNIVERSITY OF KENTUCKY · PI EVERS, BERNARD MARK, GAO, TIANYAN · 2017 to 2021
$2.1M
NCI NIH HHS R01 CA133429NCI NIH HHS R01 CA208343NIDDK NIH HHS R01 DK048498NIDDK NIH HHS R01 DK112034NIDDK NIH HHS U01 DK048489
6 · The paper itself

Abstract

Studies demonstrate a role for neurotensin (NT) in obesity and related comorbidities. Bile acid (BA) homeostasis alterations are associated with obesity. We determined the effect of NT on BA metabolism in obese and non-obese conditions. Plasma and fecal BA profiles were analyzed by LC-MS/MS in male and female NT

Indexed as

AnimalsBile Acids and SaltsCaco-2 CellsDiet, High-FatFemaleHumansIntestinesMaleMiceNeurotensinNutrientsObesityReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearBile Acids and SaltsNeurotensinNutrientsReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearcancergut hormoneshigh-fat dietmetabolismobesity

Identifiers

PMID33811694
PMCPMC9134645
OpenAlexW3144964168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.