ReviewActa diabetologica2021
Insulin and takotsubo syndrome: plausible pathophysiologic, diagnostic, prognostic, and therapeutic roles.
Review in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Takotsubo cardiomyopathy in myasthenia gravis: a systematic review of case reports with subtype-based analysis.International journal of emergency medicine · 2026Review
- Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-1: Diagnostic and Therapeutic Challenges)Balkan medical journal · 2024Article
- Insulin resistance in Takotsubo syndrome.ESC heart failure · 2024Article
- An Opportune Time to Consider Glucose-Insulin-Potassium Therapy for Takotsubo Syndrome.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023Article
- Article
- Metabolic remodeling in takotsubo syndrome.Frontiers in cardiovascular medicine · 2022Review
- Takotsubo Cardiomyopathy: Current Treatment.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
The pathophysiology of takotsubo syndrome (TTS) is elusive. Heightened adrenergic surge via the sympathetic nervous system (mainly by norepinephrine secretion) and/or elevated blood-borne catecholamines (mainly epinephrine, secreted by the adrenals) probably mediate TTS. Patients with TTS have a low prevalence of diabetes mellitus (DM), and it has been postulated that DM, via its associated neuropathy, prevents the emergence of TTS. Insulin, in animal experiments, has been shown to greatly attenuate the effects of NE on the cardiomyocytes; also, insulin in a limited clinical experience, has been found to improve heart function in patients with neurogenic stress-cardiomyopathy and TTS. Accordingly, it is postulated that high levels of insulin encountered in patients with type 2 DM are at the roots of the protective effect of DM for the emergence of TTS. Thus, a role of insulin in the pathophysiology, diagnosis, prognosis, and therapy of TTS appears to be plausible, and needs exploration.
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