Evidence map›Paper›PMID 33811281›Full record

ReviewInternational ophthalmology2021

The impact of mass spectrometry application to screen new proteomics biomarkers in Ophthalmology.

Bruno Nobre Lins Coronado, Felipe Bruno Santos da Cunha, Otávio de Toledo Nobrega, Aline Maria Araujo Martins

Abstract readReview
PubMed Publisher
In one paragraph

Review in International ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bruno Nobre Lins CoronadoSchool of Medicine, Universidade de Brasilia, Brasília, DF, Brazil. brunonobrelins@gmail.com.
Felipe Bruno Santos da CunhaTranslational Medicine Group, School of Medicine, University Center of Brasilia, Brasília, DF, Brazil.
Otávio de Toledo NobregaSchool of Medicine, Universidade de Brasilia, Brasília, DF, Brazil.
Aline Maria Araujo MartinsSchool of Medicine, Universidade de Brasilia, Brasília, DF, Brazil. alinemartins@unb.br.ORCID http://orcid.org/0000-0001-9481-0327

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn the search for molecular markers that aid in the early diagnosis and treatment of various human diseases, many studies have focused on changes in genes, their transcripts and protein products. Recent advances in proteomic methodologies, such as mass spectrometry (MS), generate new opportunities to obtain relevant information on normal and abnormal processes that occur in many important cell pathways. The human eye is a highly specialized and compartmentalized organ, and the interpretation of molecular biomarkers helps to evaluate its cellular structure, providing a broader molecular understanding that corroborates in the pathophysiology of ophthalmological diseases, with marked improvements in their diagnosis, prognosis and treatment. This review summarizes the most important protein biomarkers in Ophthalmology screened by MS tools.

conclusionThe use of translational medicine techniques (as MS), integrating basic and clinical research, still transforms scientific findings, from laboratory researches to clinical applications, from the bedside into the community.

Indexed as

OphthalmologyProteomicsBiomarkersHumansMass SpectrometryProteinsBiomarkersProteinsBiomarkersMass spectrometryOphthalmologyProteomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.