Evidence map›Paper›PMID 33811266›Full record

Trial reportAIDS and behavior2021

START (Supporting Treatment Adherence Readiness through Training) Improves Both HIV Antiretroviral Adherence and Viral Reduction, and is Cost Effective: Results of a Multi-site Randomized Controlled Trial.

Glenn J Wagner, Risa Hoffman, Sebastian Linnemayr, Stefan Schneider, Daniel Ramirez, Kyle Gordon, Rachana Seelam, Bonnie Ghosh-Dastidar

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Glenn J WagnerRAND Corporation, 1776 Main St, Santa Monica, CA, 90407, USA. gwagner@rand.org.
Risa HoffmanUCLA, Department of Medicine, Los Angeles, CA, USA.
Sebastian LinnemayrRAND Corporation, 1776 Main St, Santa Monica, CA, 90407, USA.
Stefan SchneiderLong Beach Education and Research Consultants, Long Beach, CA, USA.
Daniel RamirezLong Beach Education and Research Consultants, Long Beach, CA, USA.
Kyle GordonUCLA, Department of Medicine, Los Angeles, CA, USA.
Rachana SeelamRAND Corporation, 1776 Main St, Santa Monica, CA, 90407, USA.
Bonnie Ghosh-DastidarRAND Corporation, 1776 Main St, Santa Monica, CA, 90407, USA.

Funding

Controlled Evaluation of the Adherence Readiness Program for ART AdherenceR01MH104086 · NIMH · RAND CORPORATION · PI WAGNER, GLENN JOHN · 2015 to 2019
$2.8M
NIMH NIH HHS R01MH104086
6 · The paper itself

Abstract

The START (Supporting Treatment Adherence Readiness through Training) intervention was examined for its effects on ART adherence and virologic suppression relative to usual care. A sample of 176 clients about to start or restart ART were randomized (83 to START, 93 to usual care) at HIV clinics in the Los Angeles area. Primary outcomes included electronically monitored dose-taking adherence and HIV viral load; primary end points were months 6 and 24, with group differences examined using nonresponse-weighted means or proportions, effect sizes, and significance testing. Item nonresponse was addressed using multiple imputation. 166 (94.3%) participants started ART, of whom 124 (74.7%) were still in care at month 6, and 90 (54.2%) at month 24. In comparison to the usual care control group, the START group had higher dose-taking adherence at month 6 (86.2% vs. 71.6%, d = 0.56, p = 0.01), which was sustained through month 24 (86.0% vs. 61.1%, d =1.01, p < 0.0001). While rates of undetectable viral load did not differ between groups at month 6 or 24, the mean reduction in viral load (log

Indexed as

Anti-HIV AgentsHIV InfectionsAnti-Retroviral AgentsCost-Benefit AnalysisHumansMedication AdherenceTreatment Adherence and ComplianceViral LoadAnti-HIV AgentsAnti-Retroviral AgentsAdherenceAntiretroviralHIVInterventionRandomized controlled trial

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.