ArticleProceedings of the National Academy of Sciences of the United States of America2021
Cortical ensembles selective for context.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 73 citations in OpenAlex.
- Distinct population dimensions separate sensory adaptation and expectation-related signals in visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Emergence of Deviance Detection in Cortical Cultures Through Maturation, Criticality, and Early Experience.The European journal of neuroscience · 2026Article
- Mismatch negativity matures in adolescence and without sensitivity to microglial depletion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cortical circuit implementation of signed deviant detection with positive and negative prediction error neurons.bioRxiv : the preprint server for biology · 2026Article
- Organization, neuronal composition, and dynamics of neuronal ensembles in the songbird auditory forebrain.iScience · 2026Article
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection.Science advances · 2026Article
- Neuronal ensembles in cortical function and disease.Physiological reviews · 2026Review
- Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits.bioRxiv : the preprint server for biology · 2026Article
- Ontology-constrained multi-LLM scoring of hypothesis support in the predictive processing literature.Research square · 2026Article
- Predictive acoustical processing in human cortical layers.Nature communications · 2026Article
- Do auditory deviants evoke cortical state changes under anaesthesia? A proof-of-concept study.Experimental physiology · 2026Article
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity.bioRxiv : the preprint server for biology · 2026Article
- Global context rapidly shapes sensory responses in V1.bioRxiv : the preprint server for biology · 2026Article
- Cortical deviance detection represents a canonical difference signal.bioRxiv : the preprint server for biology · 2026Article
- Layer-specific cortical dynamics during transitions from error monitoring to decision execution in reversal learning.Communications biology · 2025Article
- Experience-Dependent Plasticity to Visual Sequences in Mouse Anterior Cingulate Cortex Reflects Familiarity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mismatch negativity develops in adolescence and independently of microglia.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Neural processing of sensory information is strongly influenced by context. For instance, cortical responses are reduced to predictable stimuli, while responses are increased to novel stimuli that deviate from contextual regularities. Such bidirectional modulation based on preceding sensory context is likely a critical component or manifestation of attention, learning, and behavior, yet how it arises in cortical circuits remains unclear. Using volumetric two-photon calcium imaging and local field potentials in primary visual cortex (V1) from awake mice presented with visual "oddball" paradigms, we identify both reductions and augmentations of stimulus-evoked responses depending, on whether the stimulus was redundant or deviant, respectively. Interestingly, deviance-augmented responses were limited to a specific subset of neurons mostly in supragranular layers. These deviance-detecting cells were spatially intermixed with other visually responsive neurons and were functionally correlated, forming a neuronal ensemble. Optogenetic suppression of prefrontal inputs to V1 reduced the contextual selectivity of deviance-detecting ensembles, demonstrating a causal role for top-down inputs. The presence of specialized context-selective ensembles in primary sensory cortex, modulated by higher cortical areas, provides a circuit substrate for the brain's construction and selection of prediction errors, computations which are key for survival and deficient in many psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.