ArticleProceedings of the National Academy of Sciences of the United States of America2021
Morphological integration of the human brain across adolescence and adulthood.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 32 citations in OpenAlex.
- A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.Biology of sex differences · 2025Article
- Sexual dimorphism and morphological integration in the orchid bee brain.Scientific reports · 2025Article
- Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025Review
- Adolescent neurocognitive development and decision-making abilities regarding gender-affirming care.Developmental cognitive neuroscience · 2024Review
- Network enrichment significance testing in brain-phenotype association studies.Human brain mapping · 2024Article
- Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence.Nature communications · 2024Article
- Very Early-Life Risk Factors for Developing Dementia: Evidence From Full Population Registers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Network Enrichment Significance Testing in Brain-Phenotype Association Studies.bioRxiv : the preprint server for biology · 2023Article
- IQ Modulates Coupling Between Diverse Dimensions of Psychopathology in Children and Adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Functional connectome fingerprinting across the lifespan.Network neuroscience (Cambridge, Mass.) · 2023Article
- Brain structure and working memory adaptations associated with maturation and aging in mice.Frontiers in aging neuroscience · 2023Article
- Article
- Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Rapid processing and quantitative evaluation of structural brain scans for adaptive multimodal imaging.Human brain mapping · 2022Article
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Brain structural covariance norms capture the coordination of neurodevelopmental programs between different brain regions. We develop and apply anatomical imbalance mapping (AIM), a method to measure and model individual deviations from these norms, to provide a lifespan map of morphological integration in the human cortex. In cross-sectional and longitudinal data, analysis of whole-brain average anatomical imbalance reveals a reproducible tightening of structural covariance by age 25 y, which loosens after the seventh decade of life. Anatomical imbalance change in development and in aging is greatest in the association cortex and least in the sensorimotor cortex. Finally, we show that interindividual variation in whole-brain average anatomical imbalance is positively correlated with a marker of human prenatal stress (birthweight disparity between monozygotic twins) and negatively correlated with general cognitive ability. This work provides methods and empirical insights to advance our understanding of coordinated anatomical organization of the human brain and its interindividual variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.