Evidence map›Paper›PMID 33811083›Full record

ArticleGenome research2021

Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication.

Vinay Tripuraneni, Gonen Memisoglu, Heather K MacAlpine, Trung Q Tran, Wei Zhu, Alexander J Hartemink, James E Haber, David M MacAlpine

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Vinay TripuraneniDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Gonen MemisogluDepartment of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA.
Heather K MacAlpineDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Trung Q TranDepartment of Computer Science, Duke University, Durham, North Carolina 27708, USA.ORCID 0000-0003-3941-1950
Wei ZhuDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Alexander J HarteminkDepartment of Computer Science, Duke University, Durham, North Carolina 27708, USA.ORCID 0000-0002-1292-2606
James E HaberDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.
David M MacAlpineDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Duke Medical Center · USDuke University · USBrandeis University · USUniversity of Chicago · US

Funding

DNA Damage Response and Repair of a Broken ChromosomeR35GM127029 · NIGMS · BRANDEIS UNIVERSITY · PI JAMES E HABER · 2018 to 2026
$8.6M
Arrest, Recovery, and Adaptation from DNA DamageR01GM061766 · NIGMS · BRANDEIS UNIVERSITY · PI HABER, JAMES E · 2001 to 2016
$4.6M
Chromatin-mediated mechanisms of genome integrityR35GM127062 · NIGMS · DUKE UNIVERSITY · PI David M MacAlpine · 2018 to 2026
$3.7M
Exploring the Role of Dynamic Chromatin Occupancy in Transcriptional RegulationR01GM118551 · NIGMS · DUKE UNIVERSITY · PI HARTEMINK, ALEXANDER J · 2016 to 2019
$1.6M
NIGMS NIH HHS R01 GM061766NIGMS NIH HHS R01 GM118551NIGMS NIH HHS R35 GM127029NIGMS NIH HHS R35 GM127062
6 · The paper itself

Abstract

We interrogated at nucleotide resolution the spatiotemporal order of chromatin changes that occur immediately following a site-specific double-strand break (DSB) upstream of the

Indexed as

DNA Breaks, Double-StrandedNucleosomesDNA-Binding ProteinsDNA End-Joining RepairDNA RepairDNA ReplicationDNA-Binding ProteinsNucleosomes

Identifiers

PMID33811083
PMCPMC8092003
OpenAlexW3144977637

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.