Evidence map›Paper›PMID 33811080›Full record

ArticleScience advances2021

Minimally invasive electroceutical catheter for endoluminal defect sealing.

Manisha Singh, Claudia E Varela, William Whyte, Markus A Horvath, Nigel C S Tan, Chee Bing Ong, Patric Liang, Marc L Schermerhorn, Ellen T Roche, Terry W J Steele

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Smart Catheters for Diagnosis, Monitoring, and Therapy.Advanced healthcare materials · 2026
    Review
  3. Biodegradable Adhesive Systems for Bio-Integrated Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Smart Internal Bio-Glues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manisha SinghNTU-Northwestern Institute for Nanomedicine (NNIN), Interdisciplinary Graduate School (IGS), Nanyang Technological University (NTU), 50 Nanyang Drive, Singapore 637553, Singapore.ORCID 0000-0002-4159-2036
Claudia E VarelaInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-8082-092X
William WhyteHarvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-2458-4149
Markus A HorvathInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-9742-8473
Nigel C S TanSchool of Materials Science and Engineering (MSE), Nanyang Technological University (NTU), Singapore 639798, Singapore.
Chee Bing OngHistopathology/Advanced Molecular Pathology Lab, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology, and Research, 61 Biopolis Drive, Singapore 138673, Singapore.ORCID 0000-0002-0521-1646
Patric LiangDivision of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Marc L SchermerhornDivision of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-4278-964X
Ellen T RocheInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. etr@mit.edu wjsteele@ntu.edu.sg.ORCID 0000-0002-8952-2993
Terry W J SteeleNTU-Northwestern Institute for Nanomedicine (NNIN), Interdisciplinary Graduate School (IGS), Nanyang Technological University (NTU), 50 Nanyang Drive, Singapore 637553, Singapore. etr@mit.edu wjsteele@ntu.edu.sg.ORCID 0000-0001-8596-9619

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in vivo and ex vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 millimeters in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudo-aneurysms/fistulas to bioelectrodes toward electrophysiological mapping.

Identifiers

PMID33811080
PMCPMC11057783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.