ArticleScience advances2021
Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 381 citations in OpenAlex.
- Mechano-immunomodulatory biomaterials: From immune mechanosensing to translational design.Bioactive materials · 2026Review
- Immune-epigenetic convergence in biomaterial-guided tissue regeneration.Materials today. Bio · 2026Article
- cGAS-STING pathway modulation: A new hope for neural regeneration.Neural regeneration research · 2026Article
- Topographical design principles for osteochondral tissue engineering.Bioactive materials · 2026Review
- Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio-Interactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Electronic Chip-Mimetic Medical Implants for Controllable Sonothermal Treatments.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Novel Strategy for Achieving Immunomodulation and Osseointegration of Titanium Alloys: Boron-Doped Porous Coating Modification.Advanced healthcare materials · 2026Article
- Defect-Mediated Sonodynamic Catalysis on Calcium-Deficient Hydroxyapatite Nanoparticles Coordinating Bacterial Elimination and Bone Regeneration against Osteomyelitis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- HOF-Stabilized Apple EV Nanocargo in an NIR-Responsive Hydrogel Enables On-Demand Therapeutic Modulation for Transdermal Deep-Joint Osteoarthritis Therapy.Advanced healthcare materials · 2026Article
- Implications of Rho GTPase signaling in cancer immunotherapy.Biochemical Society transactions · 2026Review
- Functionalizing biomaterials for osseointegration - microRNAs at the crossroads of bone formation and immune modulation.Bone & joint research · 2026Article
- Nanoparticle-Enabled Modulation of the Bone Immune Microenvironment for Enhanced Regeneration.Bioengineering (Basel, Switzerland) · 2026Review
- Bioinstructive Orthogonally-crosslinked Ovoprotein Microgels for Modular Bioprinting.bioRxiv : the preprint server for biology · 2026Article
- Review
- Full-laser-enabled clean hierarchical structuring and multifunctional synergy for high-performance in vivo 3D-printed implants.Materials today. Bio · 2026Article
- Recent advances in immunoregulatory biomaterials for tendon healing: From immune remodeling to functional regeneration.Materials today. Bio · 2026Review
- Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post-Operative Osteosarcoma Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Geometry-driven immunomodulation in 3D-printed bioceramics: Negative curvature promotes macrophage M2 polarization via Ras-MAPK/HIF-1α signaling for vascularized osteogenesis.Bioactive materials · 2026Article
- Controllable nanotopography of lysine-branched self-assembling peptide hydrogels for tendon-bone insertion regeneration.Advanced biotechnology · 2026Article
- 4D printed hydrogel scaffolds with shape morphing by near-infrared to promote bone regeneration through immune and vascular coupling.Journal of nanobiotechnology · 2026Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper immune responses are critical for successful biomaterial implantation. Here, four scales of honeycomb-like TiO
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.