Evidence map›Paper›PMID 33811041›Full record

SynthesisGut2021

Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.

Laura A Bolte, Arnau Vich Vila, Floris Imhann, Valerie Collij, Ranko Gacesa, Vera Peters, Cisca Wijmenga, Alexander Kurilshikov, Marjo J E Campmans-Kuijpers, Jingyuan Fu and 3 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 350 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

350 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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290 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laura A BolteDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.ORCID 0000-0001-6036-0831
Arnau Vich VilaDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.ORCID 0000-0003-4691-5583
Floris ImhannDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Valerie CollijDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Ranko GacesaDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Vera PetersDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Cisca WijmengaDepartment of Genetics, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Alexander KurilshikovDepartment of Genetics, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Marjo J E Campmans-KuijpersDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Jingyuan FuDepartment of Genetics, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Gerard DijkstraDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Alexandra ZhernakovaDepartment of Genetics, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.
Rinse K WeersmaDepartment of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands r.k.weersma@umcg.nl.ORCID 0000-0001-7928-7371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation.

designWe investigated the relation between 173 dietary factors and the microbiome of 1425 individuals spanning four cohorts: Crohn's disease, ulcerative colitis, irritable bowel syndrome and the general population. Shotgun metagenomic sequencing was performed to profile gut microbial composition and function. Dietary intake was assessed through food frequency questionnaires. We performed unsupervised clustering to identify dietary patterns and microbial clusters. Associations between diet and microbial features were explored per cohort, followed by a meta-analysis and heterogeneity estimation.

resultsWe identified 38 associations between dietary patterns and microbial clusters. Moreover, 61 individual foods and nutrients were associated with 61 species and 249 metabolic pathways in the meta-analysis across healthy individuals and patients with IBS, Crohn's disease and UC (false discovery rate<0.05). Processed foods and animal-derived foods were consistently associated with higher abundances of Firmicutes,

conclusionWe identified dietary patterns that consistently correlate with groups of bacteria with shared functional roles in both, health and disease. Moreover, specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects. We propose microbial mechanisms through which the diet affects inflammatory responses in the gut as a rationale for future intervention studies.

Indexed as

BeveragesDietFoodGastrointestinal MicrobiomeAdultBacteriaColitis, UlcerativeCrohn DiseaseFecesHumansInflammationIrritable Bowel SyndromeMetagenomicsMiddle AgedSurveys and QuestionnairesTime Factorsdietinflammatory bowel diseaseintestinal microbiologyirritable bowel syndromemeta-analysis

Identifiers

PMID33811041
PMCPMC8223641

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.