Evidence map›Paper›PMID 33810947›Full record

Trial reportCytokine2021

Serum IP-10 and IL-7 levels are associated with disease severity of coronavirus disease 2019.

Guo-Lin Wang, Hui-Xia Gao, Yu-Ling Wang, Xiao Wei, Yu-Zhen Liu, Jian-Hua Lu, Li Li, Hai-Bin Wang, Lei Zhao, Yan-Xiao Rong and 6 more

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in Cytokine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  9. Cytokine Profiling in Different SARS-CoV-2 Genetic Variants.International journal of molecular sciences · 2022
    Article
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  11. Article
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  13. Article
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  15. Article
  16. IP-10 and complement activation as friend or foe in COVID-19.International journal of immunopathology and pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Guo-Lin WangState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Hui-Xia GaoThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Yu-Ling WangThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Xiao WeiInstitute of Disease Control and Prevention, Chinese People's Liberation Army, Beijing, China.
Yu-Zhen LiuThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Jian-Hua LuThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Li LiThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Hai-Bin WangThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Lei ZhaoThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Yan-Xiao RongThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
Lin YaoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Li-Juan DuanState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Benjamin D AndersonGlobal Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China.
Mai-Juan MaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address: mjma@163.com.
Er-Hei DaiThe Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China. Electronic address: daieh2008@126.com.
Xiang-Na ZhaoInstitute of Disease Control and Prevention, Chinese People's Liberation Army, Beijing, China. Electronic address: xnazhao@163.com.
Hebei Medical University · CNFifth Hospital of Shijiazhuang · CNInstitute of Microbiology · CNChinese Center For Disease Control and Prevention · CNDuke Kunshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We quantified the serum levels of 34 cytokines/chemokines in 30 patients with SARS-CoV-2 infection. Elevated levels of IP-10 and IL-7 were detected in the acute and convalescent stages of the infection and were highly associated with disease severity.

Indexed as

Severity of Illness IndexChemokine CXCL10COVID-19FemaleHumansInterleukin-7MaleMiddle AgedSARS-CoV-2Chemokine CXCL10CXCL10 protein, humanInterleukin-7ChemokineCOVID-19CytokineImmune responseSARS-CoV-2

Identifiers

PMID33810947
PMCPMC7973056
OpenAlexW3137524651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.