Evidence map›Paper›PMID 33810327›Full record

ArticleMolecules (Basel, Switzerland)2021

Acidified Nitrite Accelerates Wound Healing in Type 2 Diabetic Male Rats: A Histological and Stereological Evaluation.

Hamideh Afzali, Mohammad Khaksari, Sajad Jeddi, Khosrow Kashfi, Mohammad-Amin Abdollahifar, Asghar Ghasemi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Hamideh AfzaliEndocrinology and Metabolism Research, and Physiology Research Centers, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
Mohammad KhaksariEndocrinology and Metabolism Research, and Physiology Research Centers, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
Sajad JeddiEndocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
Khosrow KashfiDepartment of Molecular, Cellular and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, New York, NY 10031, USA.ORCID 0000-0002-4060-7283
Mohammad-Amin AbdollahifarDepartment of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.
Asghar GhasemiEndocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1985717413, Iran.ORCID 0000-0001-6867-2151
Kerman University of Medical Sciences · IRResearch Institute for Endocrine Sciences · IRCity University of New York · USShahid Beheshti University of Medical Sciences · IR

Funding

Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences 97061
6 · The paper itself

Abstract

Impaired skin nitric oxide production contributes to delayed wound healing in type 2 diabetes (T2D). This study aims to determine improved wound healing mechanisms by acidified nitrite (AN) in rats with T2D. Wistar rats were assigned to four subgroups: Untreated control, AN-treated control, untreated diabetes, and AN-treated diabetes. AN was applied daily from day 3 to day 28 after wounding. On days 3, 7, 14, 21, and 28, the wound levels of vascular endothelial growth factor (VEGF) were measured, and histological and stereological evaluations were performed. AN in diabetic rats increased the numerical density of basal cells (1070 ± 15.2 vs. 936.6 ± 37.5/mm

Indexed as

AnimalsCitric AcidCollagenDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2MaleNeovascularization, PhysiologicRatsRats, Sprague-DawleyRats, WistarSkinSkin CreamSodium NitriteVascular Endothelial Growth Factor AWound HealingCitric AcidCollagenSodium NitriteVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratacidified nitritediabetic woundhistologyhydroxyprolinenitric oxidetype 2 diabetesVEGF

Identifiers

PMID33810327
PMCPMC8037216
OpenAlexW3139873462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.