Evidence map›Paper›PMID 33810274›Full record

ArticleInternational journal of molecular sciences2021

Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells.

Claudio Luparello, Ilenia Cruciata, Andreas C Joerger, Cory A Ocasio, Rhiannon Jones, Raysa Khan Tareque, Mark C Bagley, John Spencer, Martin Walker, Carol Austin and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Journal of enzyme inhibition and medicinal chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Claudio LuparelloDepartment of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy.ORCID 0000-0001-9821-5891
Ilenia CruciataDepartment of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy.ORCID 0000-0002-6614-7270
Andreas C JoergerInstitute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany.
Cory A OcasioDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK.ORCID 0000-0002-4957-4131
Rhiannon JonesDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK.
Raysa Khan TarequeDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK.
Mark C BagleyDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK.ORCID 0000-0003-1263-138X
John SpencerDepartment of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK.ORCID 0000-0001-5231-8836
Martin WalkerEurofins Integrated Discovery UK Ltd., Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, UK.
Carol AustinEurofins Integrated Discovery UK Ltd., Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, UK.
Tiziana FerraraDepartment of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy.
Pietro D OcaDepartment of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy.
Rossella BellinaDepartment of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy.
Rossella BranniDepartment of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy.
Fabio CaradonnaDepartment of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy.ORCID 0000-0002-7659-7312
University of Palermo · ITUniversity of Sussex · GBC4X Discovery (United Kingdom) · GBGoethe University Frankfurt · DE

Funding

EUbOPEN 875510EU/EFPIA/OICR/McGill/ KTH/Diamond no numberEuropean Regional Development Fund LabFact: InterReg V project 121Ewart Bequest fund no numberGerman Research Foundation JO 1473/1-1German Research Foundation JO 1473/1-3Janssen no numberMerck & Co no numberMerck KGaA no numberPfizer no numberSão Paulo Research Foundation-FAPESP no numberSGC charity no numberTakeda no numberUniversità degli Studi di Palermo FFR 2018Università degli Studi di Palermo FFR 2020University of Sussex no numberWellcome 106169/ZZ14/ZWorldwide Cancer Research 14-1002Worldwide Cancer Research 18-0043
6 · The paper itself

Abstract

The carbazole compounds

Indexed as

Antineoplastic AgentsBreast NeoplasmsCarbazolesDNA DamageDNA MethylationEpigenesis, GeneticFemaleHistonesHumansMCF-7 CellsMutagensSignal TransductionTumor Suppressor Protein p53Antineoplastic AgentsCarbazolesHistonesMutagensTP53 protein, humanTumor Suppressor Protein p53breast cancercarbazole derivativesDNA methylationepigeneticsgenomic instability

Identifiers

PMID33810274
PMCPMC8038095
OpenAlexW3140958618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.