ReviewPolymers2021
The Role of Surface Chemistry in the Efficacy of Protein and DNA Microarrays for Label-Free Detection: An Overview.
Review in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- A Bimodal Graph Neural Network with Transfer Learning and Contrastive Learning for Protein-Protein Interaction Site Prediction.Interdisciplinary sciences, computational life sciences · 2026Article
- Emerging biosensors integrated with microfluidic devices: a promising analytical tool for on-site detection of mycotoxins.NPJ science of food · 2025Review
- Protein Orientation and Polymer Phase Separation Induced by Poly(methyl methacrylate) Tacticity.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Imaging Diffractometric Biosensors for Label-Free, Multi-Molecular Interaction Analysis.Biosensors · 2024Article
- Characterization of Receptor Binding Affinity for Vascular Endothelial Growth Factor with Interferometric Imaging Sensor.Biosensors · 2024Article
- Multiplex Microarrays in 96-Well Plates Photoactivated with 4-Azidotetrafluorobenzaldehyde for the Identification and Quantification of β-Lactamase Genes and Their RNA Transcripts.Current issues in molecular biology · 2023Article
- Precise surface functionalization of PLGA particles for human T cell modulation.Nature protocols · 2023Article
- Optimization of Functional Group Concentration of N, N-Dimethylacrylamide-based Polymeric Coatings and Probe Immobilization for DNA and Protein Microarray Applications.Micromachines · 2023Article
- Label-free optical biosensors in the pandemic era.Nanophotonics (Berlin, Germany) · 2022Review
- Universal control of proton concentration using an electrochemically generated acid compatible with miniaturization.Nanoscale advances · 2022Article
- The Effects of Three-Dimensional Ligand Immobilization on Kinetic Measurements in Biosensors.Polymers · 2022Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The importance of microarrays in diagnostics and medicine has drastically increased in the last few years. Nevertheless, the efficiency of a microarray-based assay intrinsically depends on the density and functionality of the biorecognition elements immobilized onto each sensor spot. Recently, researchers have put effort into developing new functionalization strategies and technologies which provide efficient immobilization and stability of any sort of molecule. Here, we present an overview of the most widely used methods of surface functionalization of microarray substrates, as well as the most recent advances in the field, and compare their performance in terms of optimal immobilization of the bioreceptor molecules. We focus on label-free microarrays and, in particular, we aim to describe the impact of surface chemistry on two types of microarray-based sensors: microarrays for single particle imaging and for label-free measurements of binding kinetics. Both protein and DNA microarrays are taken into consideration, and the effect of different polymeric coatings on the molecules' functionalities is critically analyzed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.