ReviewMolecules (Basel, Switzerland)2021
Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Fluorescence Quenching Properties and Bioimaging Applications of Readily Accessible Blue to Far-Red Fluorogenic Triazinium Salts.Journal of the American Chemical Society · 2026Article
- Expanding the multiplexing capability of HIDE probes via fluorescence lifetime imaging microscopy.Methods in enzymology · 2026Article
- Tetrazine-enhanced donor-acceptor-donor metal-organic frameworks for photodynamic antibacterial therapy and wound healing.Nature communications · 2025Article
- Difluoroboronated tetrazine probes for rapid bioorthogonal fluorescence activation, no-wash STED imaging, and triggered drug release.Science advances · 2025Article
- Supramolecular Guest Exchange in Cucurbit[7]uril for Bioorthogonal Fluorogenic Imaging across the Visible Spectrum.ACS central science · 2024Article
- Readily Accessible and Brightly Fluorogenic BODIPY/NBD-Tetrazines via SThe Journal of organic chemistry · 2024Article
- An all-in-one tetrazine reagent for cysteine-selective labeling and bioorthogonal activable prodrug construction.Nature communications · 2024Article
- Fluorogenic Reactions in Chemical Biology: Seeing Chemistry in Cells.Chemical & biomedical imaging · 2023Review
- Triazine Chalcogenones from Thiocyanate or Selenocyanate Addition to Tetrazine Ligands in Ruthenium Arene Complexes.Inorganic chemistry · 2023Article
- Green Synthesis of Aromatic Nitrogen-Containing Heterocycles by Catalytic and Non-Traditional Activation Methods.Molecules (Basel, Switzerland) · 2023Review
- [3+2] click chemistry approach to tetrazine containing polymers.RSC advances · 2022Article
- Rational Design for High Bioorthogonal Fluorogenicity of Tetrazine-Encoded Green Fluorescent Proteins.Natural sciences (Weinheim, Germany) · 2022Article
- Bioorthogonally activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging.Nature communications · 2022Article
- Synthesis and Luminescent Properties ofMolecules (Basel, Switzerland) · 2022Article
- Novel ConjugatedMolecules (Basel, Switzerland) · 2022Article
- Color-Tunable Indolizine-Based Fluorophores and Fluorescent pH Sensor.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
Various bioorthogonal chemistries have been used for fluorescent imaging owing to the advantageous reactions they employ. Recent advances in bioorthogonal chemistry have revolutionized labeling strategies for fluorescence imaging, with inverse electron demand Diels-Alder (iEDDA) reactions in particular attracting recent attention owing to their fast kinetics and excellent specificity. One of the most interesting features of the iEDDA labeling strategy is that tetrazine-functionalized dyes are known to act as fluorogenic probes. In this review, we will focus on the synthesis, molecular-design strategies, and bioimaging applications of tetrazine-functionalized fluorogenic probes. Traditional Pinner reaction and "Pinner-like" reactions for tetrazine synthesis are discussed here, as well as metal-catalyzed C-C bond formations with convenient tetrazine intermediates and the fabrication of tetrazine-conjugated fluorophores. In addition, four different quenching mechanisms for tetrazine-modified fluorophores are presented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.