Evidence map›Paper›PMID 33810045›Full record

ArticleInternational journal of molecular sciences2021

Sesquiterpene Lactone Deoxyelephantopin Isolated from

Biljana Cvetanova, Meng-Yi Li, Chung-Chih Yang, Pei-Wen Hsiao, Yu-Chih Yang, Jia-Hua Feng, Ya-Ching Shen, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  9. Evasion of NK cell immune surveillanceFrontiers in immunology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Biljana CvetanovaSchool of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Meng-Yi LiAgricultural Biotechnology Research Center, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
Chung-Chih YangAgricultural Biotechnology Research Center, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
Pei-Wen HsiaoAgricultural Biotechnology Research Center, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
Yu-Chih YangAgricultural Biotechnology Research Center, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
Jia-Hua FengAgricultural Biotechnology Research Center, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
Ya-Ching ShenSchool of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Kyoko Nakagawa-GotoSchool of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.ORCID 0000-0002-1642-6538
Kuo-Hsiung LeeDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA.ORCID 0000-0002-6562-0070
Lie-Fen ShyurAgricultural Biotechnology Research Center, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
Agricultural Biotechnology Research Center, Academia Sinica · TWNational Taiwan University · TWKanazawa University · JPNational Sun Yat-sen University · TWUniversity of North Carolina at Chapel Hill · US

Funding

Ministry of Science and Technology, Taiwan and Academia Sinica, Taiwan MOST 106-2320-B-001-004-MY3, MOST 109-2320-B-001 -019 -MY3, AS-SUMMIT-108
6 · The paper itself

Abstract

Melanoma is a highly metastatic disease with an increasing rate of incidence worldwide. It is treatment refractory and has poor clinical prognosis; therefore, the development of new therapeutic agents for metastatic melanoma are urgently required. In this study, we created a lung-seeking A375LM5

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisAsteraceaeCell Cycle CheckpointsCell Line, TumorCell ProliferationDisease Models, AnimalHumansImmunohistochemistryLactonesLung NeoplasmsMelanomaMiceMitochondriaMolecular StructureAntineoplastic Agents, PhytogenicdeoxyelephantopinLactonesPlant ExtractsProto-Oncogene Proteins B-rafReactive Oxygen SpeciesSesquiterpenesBRAFV600E metastatic melanomadeoxyelephantopinDETD-35mitochondria dysfunctionoxidative stress

Identifiers

PMID33810045
PMCPMC8004649
OpenAlexW3137673976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.