1,3-Cyclohexadien-1-Als: Synthesis, Reactivity and Bioactivities.

Ignacio E Tobal, Rocío Bautista, David Diez, Narciso M Garrido, Pilar García-García

Abstract readReview

In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ignacio E TobalDepartamento de Química Orgánica, Facultad de Ciencias Químicas, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain.ORCID 0000-0001-8781-6245

Rocío BautistaDepartamento de Química Orgánica, Facultad de Ciencias Químicas, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain.ORCID 0000-0002-9386-8495

David DiezDepartamento de Química Orgánica, Facultad de Ciencias Químicas, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain.ORCID 0000-0002-7261-8454

Narciso M GarridoDepartamento de Química Orgánica, Facultad de Ciencias Químicas, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain.ORCID 0000-0002-1704-8073

Pilar García-GarcíaDepartamento de Ciencias Farmacéuticas, Facultad de Farmacia, CIETUS, IBSAL, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.ORCID 0000-0003-0740-9151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In synthetic organic chemistry, there are very useful basic compounds known as building blocks. One of the main reactions wherein they are applied for the synthesis of complex molecules is the Diels-Alder cycloaddition. This reaction is between a diene and a dienophile. Among the most important dienes are the cyclic dienes, as they facilitate the reaction. This review considers the synthesis and reactivity of one of these dienes with special characteristics-it is cyclic and has an electron withdrawing group. This building block has been used for the synthesis of biologically active compounds and is present in natural compounds with interesting properties.

Indexed as

Cycloaddition ReactionPolyenesMolecular StructureStereoisomerismPolyenesaldehydeschiral compoundsDiels–Alderdienessynthesis

Identifiers

PMID33809941

DOI10.3390/molecules26061772

PMCPMC8004145

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.