Evidence map›Paper›PMID 33809907›Full record

ArticleGenes2021

Pilot Study to Detect Genes Involved in DNA Damage and Cancer in Humans: Potential Biomarkers of Exposure to E-Cigarette Aerosols.

Samera H Hamad, Marielle C Brinkman, Yi-Hsuan Tsai, Namya Mellouk, Kandice Cross, Ilona Jaspers, Pamela I Clark, Courtney A Granville

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Impact of Electronic Nicotine Delivery Systems on Oral Mucosa: A Cytopathological and Molecular Study.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
  2. Article
  3. E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Review
  4. E-cigarette: a safe tool or a risk factor for oral cancer? A systematic review.Journal of clinical and experimental dentistry · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. The Toxicological Effects of e-Cigarette Use in the Upper Airway: A Scoping Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024
    Article
  9. Article
  10. Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  11. Review
  12. Review
  13. Electronic Cigarettes: A Pro-Con Review of the Current Literature.The journal of allergy and clinical immunology. In practice · 2022
    Review
  14. E-Cigarette Toxicology.Annual review of pharmacology and toxicology · 2022
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Samera H HamadUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Marielle C BrinkmanCollege of Public Health, Ohio State University, Columbus, OH 43210, USA.
Yi-Hsuan TsaiUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Namya MelloukNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Kandice CrossGad Consulting Services, Risk Assessment, Consulting in Raleigh, Raleigh, NC 27609, USA.
Ilona JaspersCurriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Pamela I ClarkSchool of Public Health, University of Maryland, College Park, MD 20742, USA.
Courtney A GranvilleDrug Information Association, Washington, DC 20036, USA.
University of North Carolina at Chapel Hill · USGad Consulting Services (United States) · USThe Ohio State University · USTriangle · USUniversity of Maryland, College Park · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Rapid Response Characterization of New and Manipulated Tobacco ProductsP50CA180523 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI CLARK, PAMELA I · 2013 to 2017
$19.0M
NIEHS NIH HHS P30 ES010126NIH HHS P50CA180523
6 · The paper itself

Abstract

There is a paucity of data on how gene expression enables identification of individuals who are at risk of exposure to carcinogens from e-cigarette (e-cig) vaping; and how human vaping behaviors modify these exposures. This pilot study aimed to identify genes regulated from acute exposure to e-cig using RT-qPCR. Three subjects (2M and 1F) made three visits to the lab (n

Indexed as

DNA DamageDNA GlycosylasesDown-RegulationElectronic Nicotine Delivery SystemsFeasibility StudiesFemaleGene Expression RegulationHumansMaleMouthNeoplasmsNicotinePilot ProjectsTumor Suppressor Protein p53Up-RegulationDNA-3-methyladenine glycosidase IIDNA GlycosylasesNicotineTP53 protein, humanTumor Suppressor Protein p53biomarkersDNA damageelectronic cigarettesgene expressionhuman buccal and bloodvaping behaviors

Identifiers

PMID33809907
PMCPMC8004185
OpenAlexW3136327354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.