ArticleNanomaterials (Basel, Switzerland)2021
Electrospun PCL-Based Vascular Grafts: In Vitro Tests.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Evaluation of the Biological Response to Coating 3D-Printed PLA Scaffolds with Coaxial Gelatin-Based Electrospun Fibers.Biomimetics (Basel, Switzerland) · 2026Article
- ProlongedACS omega · 2026Article
- Laminin-conjugated aligned nanofiber yarns for topographical and biochemical guidance of neurite outgrowth and branching regulation.Journal of nanobiotechnology · 2025Article
- Novel Magnetically Charged Grafts for Vascular Repair: Process Optimization, Mechanical Characterization and In Vitro Validation.Polymers · 2025Article
- A study on the cellular adhesion properties of a hybrid scaffold for vascular tissue engineering through molecular dynamics simulation.Scientific reports · 2025Article
- Hydrogel inspired by "adobe" with antibacterial and antioxidant properties for diabetic wound healing.Materials today. Bio · 2025Article
- Influence of Different Solvents on the Mechanical Properties of Electrospun Scaffolds.Materials (Basel, Switzerland) · 2025Article
- Enhancing Bone Repair with β-TCP-Based Composite Scaffolds: A Review of Design Strategies and Biological Mechanisms.Orthopedic research and reviews · 2025Review
- Optimization of Diclofenac-Loaded Bicomponent Nanofibers: Effect of Gelatin on In Vitro and In Vivo Response.Pharmaceutics · 2024Article
- Electrospun Chitosan-Based Nanofibrous Coating for the Local and Sustained Release of Vancomycin.ACS omega · 2024Article
- Electrospun bioresorbable polymer membranes for coronary artery stents.Frontiers in bioengineering and biotechnology · 2024Article
- The Manufacturing Conditions for the Direct and Reproducible Formation of Electrospun PCL/Gelatine 3D Structures for Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2023Article
- Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts.Polymers · 2023Review
- Osteoinductive Electrospun Scaffold Based on PCL-Col as a Regenerative Therapy for Peri-Implantitis.Pharmaceutics · 2023Article
- Crimped fiber composites: mechanics of a finite-length crimped fiber embedded in a soft matrix.Biomechanics and modeling in mechanobiology · 2023Article
- PCL/Gelatin/Graphene Oxide Electrospun Nanofibers: Effect of Surface Functionalization on In Vitro and Antibacterial Response.Nanomaterials (Basel, Switzerland) · 2023Article
- Playing with Biophysics: How a Symphony of Different Electromagnetic Fields Acts to Reduce the Inflammation in Diabetic Derived Cells.International journal of molecular sciences · 2023Article
- Polyurethane/Liquid Crystal Microfibers with pDNA Polyplex Loadings for the Optimal Release and Promotion of HUVEC Proliferation.Pharmaceutics · 2022Article
- Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges.Cells · 2022Review
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrospun fibers have attracted a lot of attention from researchers due to their several characteristics, such as a very thin diameter, three-dimensional topography, large surface area, flexible surface, good mechanical characteristics, suitable for widespread applications. Indeed, electro-spinning offers many benefits, such as great surface-to-volume ratio, adjustable porosity, and the ability of imitating the tissue extra-cellular matrix.
methodswe processed Poly ε-caprolactone (PCL) via electrospinning for the production of bilayered tubular scaffolds for vascular tissue engineering application. Endothelial cells and fibroblasts were seeded into the two side of the scaffolds: endothelial cells onto the inner side composed of PCL/Gelatin fibers able to mimic the inner surface of the vessels, and fibroblasts onto the outer side only exposing PCL fibers. Extracellular matrix production and organization has been performed by means of classical immunofluorescence against collagen type I fibers, Scanning Electron-Microscopy (SEM) has been performed in order to evaluated ultrastructural morphology, gene expression by means gene expression has been performed to evaluate the phenotype of endothelial cells and fibroblasts. RESULTS AND
conclusionresults confirmed that both cells population are able to conserve their phenotype colonizing the surface supporting the hypothesis that PCL scaffolds based on electrospun fibers should be a good candidate for vascular surgery.
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