ArticleMolecules (Basel, Switzerland)2021
Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Inhibiting The uPA/uPAR Pathway Affords Photoreceptor Resilience and Preserves Retinal Function in a Mouse Model of Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2025Article
- Turn-Adopting Peptidomimetic as a Formyl Peptide Receptor-1 Antagonist.ACS pharmacology & translational science · 2024Article
- Synthesis of Natural and Sugar-Modified Nucleosides Using the Iodine/Triethylsilane System asInternational journal of molecular sciences · 2024Article
- Peptide Functionalization of Emulsion-Based Nanocarrier to Improve Uptake across Blood-Brain Barrier.Pharmaceutics · 2024Article
- Assessing the Potential ofACS pharmacology & translational science · 2024Article
- Synthesis and Biological Evaluation of New Dihydrofuro[3,2-Molecules (Basel, Switzerland) · 2024Article
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Authors and funding
4 authors.
Funding
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Abstract
The de novo synthesis of piperidine nucleosides from our homologating agent 5,6-dihydro-1,4-dithiin is herein reported. The structure and conformation of nucleosides were conceived to faithfully resemble the well-known nucleoside drugs Immucillins H and A in their bioactive conformation. NMR analysis of the synthesized compounds confirmed that they adopt an iminosugar conformation bearing the nucleobases and the hydroxyl groups in the appropriate orientation.
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Registered trials
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