Evidence map›Paper›PMID 33809487›Full record

ArticleAnimals : an open access journal from MDPI2021

Metabolic Profile Reveals the Immunosuppressive Mechanisms of Methionyl-Methionine in Lipopolysaccharide-Induced Inflammation in Bovine Mammary Epithelial Cell.

Wei Lan, Yifei Ren, Zhen Wang, Jianxin Liu, Hongyun Liu

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei LanCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-8257-9981
Yifei RenCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Zhen WangCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Jianxin LiuCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-5812-5186
Hongyun LiuCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-8806-6204
Zhejiang University · CN

Funding

National Natural Science Foundation of China 31872989
6 · The paper itself

Abstract

Our previous transcriptomic study found that methionyl-methionine (Met-Met) exerts an anti-inflammatory effect in the bovine mammary epithelial cell (MAC-T) at a molecular level. However, evidence of whether the metabolic production of Met-Met confers protection was scarce. To investigate the inflammatory response and metabolite changes of Met-Met in lipopolysaccharide (LPS)-induced inflammation of MAC-T, mass spectrometry-based metabolomics and qPCR were conducted. The increased levels of

Indexed as

inflammationlipopolysaccharideMAC-TMet-Met

Identifiers

PMID33809487
PMCPMC8000761
OpenAlexW3139058852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.