Evidence map›Paper›PMID 33809401›Full record

ReviewToxins2021

Wasp Venom Biochemical Components and Their Potential in Biological Applications and Nanotechnological Interventions.

Aida Abd El-Wahed, Nermeen Yosri, Hanem H Sakr, Ming Du, Ahmed F M Algethami, Chao Zhao, Ahmed H Abdelazeem, Haroon Elrasheid Tahir, Saad H D Masry, Mohamed M Abdel-Daim and 6 more

Abstract readReview
In one paragraph

Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Aida Abd El-WahedAgricultural Research Centre, Department of Bee Research, Plant Protection Research Institute, Giza 12627, Egypt.
Nermeen YosriDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.
Hanem H SakrDepartment of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.
Ming DuNational Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.ORCID 0000-0001-5872-8529
Ahmed F M AlgethamiAlnahalaljwal Foundation Saudi Arabia, P.O. Box 617, Al Jumum 21926, Makkah, Saudi Arabia.
Chao ZhaoCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0000-0003-1096-632X
Ahmed H AbdelazeemDepartment of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.ORCID 0000-0002-0599-3393
Haroon Elrasheid TahirSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
Saad H D MasryAbu Dhabi Food Control Authority, Al Ain 52150, United Arab Emirates.
Mohamed M Abdel-DaimPharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0002-4341-2713
Syed Ghulam MusharrafInternational Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan.
Islam El-GarawaniDepartment of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.ORCID 0000-0002-7241-4910
Guoyin KaiLaboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China.ORCID 0000-0001-7586-9067
Yahya Al NaggarGeneral Zoology, Institute for Biology, Martin Luther University Halle-Wittenberg, Hoher Weg 8, 06120 Halle (Saale), Germany.
Shaden A M KhalifaDepartment of Molecular Biosciences, Stockholm University, the Wenner-Gren Institute, SE-106 91 Stockholm, Sweden.
Hesham R El-SeediDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wasps, members of the order Hymenoptera, are distributed in different parts of the world, including Brazil, Thailand, Japan, Korea, and Argentina. The lifestyles of the wasps are solitary and social. Social wasps use venom as a defensive measure to protect their colonies, whereas solitary wasps use their venom to capture prey. Chemically, wasp venom possesses a wide variety of enzymes, proteins, peptides, volatile compounds, and bioactive constituents, which include phospholipase A2, antigen 5, mastoparan, and decoralin. The bioactive constituents have anticancer, antimicrobial, and anti-inflammatory effects. However, the limited quantities of wasp venom and the scarcity of advanced strategies for the synthesis of wasp venom's bioactive compounds remain a challenge facing the effective usage of wasp venom. Solid-phase peptide synthesis is currently used to prepare wasp venom peptides and their analogs such as mastoparan, anoplin, decoralin, polybia-CP, and polydim-I. The goal of the current review is to highlight the medicinal value of the wasp venom compounds, as well as limitations and possibilities. Wasp venom could be a potential and novel natural source to develop innovative pharmaceuticals and new agents for drug discovery.

Indexed as

NanotechnologyAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsAntineoplastic AgentsHumansInsect ProteinsWasp VenomsAnti-Infective AgentsAnti-Inflammatory AgentsAntineoplastic AgentsInsect ProteinsWasp Venomsallergybioactive compoundsbiomedical propertiesnanotechnology applicationswasp’s venom

Identifiers

PMID33809401
PMCPMC8000949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.