Evidence map›Paper›PMID 33809369›Full record

ReviewInternational journal of molecular sciences2021

Investigating T Cell Immunity in Cancer: Achievements and Prospects.

Zhen Zeng, Hui Yi Chew, Jazmina G Cruz, Graham R Leggatt, James W Wells

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. The Interplay of Autoimmune Disease, Cancer, and Immunity: Current Understanding and Therapeutic Prospects.International journal of hematology-oncology and stem cell research · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Modeling immune checkpoint inhibitor associated myocarditisJournal of molecular and cellular cardiology plus · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Assessing a single-cell multi-omic analytic platform to characterizeFrontiers in bioengineering and biotechnology · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhen ZengDiamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0002-8120-0973
Hui Yi ChewDiamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
Jazmina G CruzDiamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
Graham R LeggattDiamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0002-4078-5653
James W WellsDiamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.ORCID 0000-0002-9618-6940
The University of Queensland · AU

Funding

National Health and Medical Research Council 1099999National Health and Medical Research Council 2000135
6 · The paper itself

Abstract

T cells play a key role in tumour surveillance, both identifying and eliminating transformed cells. However, as tumours become established they form their own suppressive microenvironments capable of shutting down T cell function, and allowing tumours to persist and grow. To further understand the tumour microenvironment, including the interplay between different immune cells and their role in anti-tumour immune responses, a number of studies from mouse models to clinical trials have been performed. In this review, we examine mechanisms utilized by tumour cells to reduce their visibility to CD8

Indexed as

ImmunotherapyAnimalsCD8-Positive T-LymphocytesHumansMiceNeoplasmsT-LymphocytesT-Lymphocytes, CytotoxicTumor MicroenvironmentcancerCARCD8 T cellscheckpoint inhibitorcytotoxic T lymphocytesimmunotherapytumour antigen

Identifiers

PMID33809369
PMCPMC7999898
OpenAlexW3138557368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.