Evidence map›Paper›PMID 33809333›Full record

ArticleGenes2021

Spt4 Promotes Pol I Processivity and Transcription Elongation.

Abigail K Huffines, Yvonne J K Edwards, David A Schneider

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Abigail K HuffinesDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham 720 20th Street South, Birmingham, AL 35294, USA.
Yvonne J K EdwardsDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham 720 20th Street South, Birmingham, AL 35294, USA.ORCID 0000-0001-8505-3168
David A SchneiderDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham 720 20th Street South, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · US

Funding

Control of RNA polymerase I transcription initiation and elongationR01GM084946 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2020
$3.8M
UNDERSTANDING THE ROLES OF RNA POLYMERASE I IN TRANSCRIPTION AND BEYONDR35GM140710 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2021 to 2025
$2.1M
NIGMS NIH HHS GM084946NIGMS NIH HHS R01 GM084946NIGMS NIH HHS R35 GM140710
6 · The paper itself

Abstract

RNA polymerases (Pols) I, II, and III collectively synthesize most of the RNA in a eukaryotic cell. Transcription by Pols I, II, and III is regulated by hundreds of trans-acting factors. One such protein, Spt4, has been previously identified as a transcription factor that influences both Pols I and II. Spt4 forms a complex with Spt5, described as the Spt4/5 complex (or DSIF in mammalian cells). This complex has been shown previously to directly interact with Pol I and potentially affect transcription elongation. The previous literature identified defects in transcription by Pol I when

Indexed as

Chromosomal Proteins, Non-HistoneDNA-Directed RNA PolymerasesDNA, RibosomalNuclear ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscriptional Elongation FactorsTranscription FactorsTranscription, GeneticChromosomal Proteins, Non-HistoneDNA-Directed RNA PolymerasesDNA, RibosomalNuclear ProteinsSaccharomyces cerevisiae ProteinsSPT4 protein, S cerevisiaeSPT5 transcriptional elongation factorTranscriptional Elongation FactorsTranscription FactorsribosomeRNA polymerase IrRNASpt4transcription

Identifiers

PMID33809333
PMCPMC8000598
OpenAlexW3137349031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.