Evidence map›Paper›PMID 33809306›Full record

ArticleCancers2021

Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes.

Vasilis S Dionellis, Maxim Norkin, Angeliki Karamichali, Giacomo G Rossetti, Joerg Huelsken, Paloma Ordonez-Moran, Thanos D Halazonetis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Vasilis S DionellisDepartment of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland.
Maxim NorkinCancer Stem Cell Laboratory, Swiss Institute of Technology Lausanne (EPFL), ISREC, 1015 Lausanne, Switzerland.
Angeliki KaramichaliDepartment of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland.
Giacomo G RossettiDepartment of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0002-8272-2925
Joerg HuelskenCancer Stem Cell Laboratory, Swiss Institute of Technology Lausanne (EPFL), ISREC, 1015 Lausanne, Switzerland.
Paloma Ordonez-MoranDivision of Cancer & Stem Cells, School of Medicine, Centre for Cancer Sciences, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0001-7688-1252
Thanos D HalazonetisDepartment of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland.
University of Geneva · CHÉcole Polytechnique Fédérale de Lausanne · CHUniversity of Nottingham · GB

Funding

Carigest Foundation S19176
6 · The paper itself

Abstract

The genomes of many human CRCs have been sequenced, revealing a large number of genetic alterations. However, the molecular mechanisms underlying the accumulation of these alterations are still being debated. In this study, we examined colorectal tumours that developed in mice with

Indexed as

cancer driverscolorectal cancercopy number alterationsexome sequencinggenomic instabilitymouse modelsmutational signatureorganoidssingle cellsingle nucleotide variants

Identifiers

PMID33809306
PMCPMC7999300
OpenAlexW3137142089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.