Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors at 3 institutions in 2 countries.
Mariano GolubickiOncology Section, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.ORCID 0000-0002-3773-8581
Marcos Díaz-GayCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.ORCID 0000-0003-0658-0467
Laia BonjochCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.ORCID 0000-0002-3351-0037
Sebastià Franch-ExpósitoCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.
Jenifer MuñozCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.
Teresa OcañaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.
Soledad IseasOncology Section, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.
Guillermo MendezOncology Section, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.
Marcela CarballidoOncology Section, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.
Juan RobbioOncology Section, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.ORCID 0000-0002-3616-1709
Daniel CisternaMolecular Biology Lab, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.ORCID 0000-0001-7614-9272
Enrique RocaOncology Section, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.
Antoni CastellsCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.ORCID 0000-0001-8431-2033
Francesc BalaguerCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.ORCID 0000-0002-0206-0539
Sergi Castellví-BelCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Gastroenterology Department, Institut d' Investigacions BiomèdiquesAugust Pi i Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain.ORCID 0000-0003-1217-5097
Marina AnteloOncology Section, Hospital of Gastroenterology "Dr. C. B. Udaondo", Buenos Aires C1264, Argentina.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESHospital Clínic de Barcelona · ESUniversity of California San Diego · US
Funding
Agència de Gestió d'Ajuts Universitaris i de Recerca 2019FI_B2_00203Centres de Recerca de Catalunya GRPRE 2017SGR21, GRC 2017SGR653European Cooperation in Science and Technology COST Action CA17118Fondation Nelia et Amadeo Barletta Antelo-2017Fondo de Investigación Sanitaria/FEDER 17/00878, 20/00113
6 · The paper itself
Abstract
Lynch-like syndrome (LLS) is an increasingly common clinical challenge with an underlying molecular basis mostly unknown. To shed light onto it, we focused on a very young LLS early-onset colorectal cancer (CRC) cohort (diagnosis ≤ 40 y.o.), performing germline and tumor whole-exome sequencing (WES) of 15 patients, and additionally analyzing their corresponding tumor mutational burden (TMB) and mutational signatures. We identified four cases (27%) with double somatic putative variants in mismatch repair (MMR) core genes, as well as three additional cases (20%) with double
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Comprehensive Genomic Characterization of Fifteen Early-Onset Lynch-Like Syndrome Colorectal Cancers. · full record | OpenQuestion