Evidence map›Paper›PMID 33809178›Full record

ArticleInternational journal of molecular sciences2021

Mycobacterial Epoxide Hydrolase EphD Is Inhibited by Urea and Thiourea Derivatives.

Jan Madacki, Martin Kopál, Mary Jackson, Jana Korduláková

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Structural isomerisation affects the antitubercular activity of adamantyl-isoxyl adducts.Journal of enzyme inhibition and medicinal chemistry · 2025
    Article
  3. Article
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  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jan MadackiDepartment of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská Dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.
Martin KopálDepartment of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská Dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1682, USA.
Jana KordulákováDepartment of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská Dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0003-2834-0165
Comenius University Bratislava · SKColorado State University · US

Funding

MmpL3 as a target for novel anti-TB agentsR01AI116525 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2015 to 2024
$5.3M
Inhibitors of Mycobacterium tuberculosis FAS-II dehydratasesR21AI153477 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2020 to 2021
$376k
National Institute of Allergy and Infectious Diseases AI116525National Institute of Allergy and Infectious Diseases AI153477NIAID NIH HHS R01 AI116525NIAID NIH HHS R21 AI153477Slovak Research and Development Agency APVV-19-0189
6 · The paper itself

Abstract

The genome of the human intracellular pathogen

Indexed as

AdamantaneEpoxide HydrolasesGene Expression Regulation, BacterialHumansMycobacterium tuberculosisPhenylurea CompoundsThioacetazoneThioureaTuberculosisUrea1-(2-adamantyl)-3-(2,3,4-trifluorophenyl)ureaAdamantaneEpoxide HydrolasesPhenylurea CompoundsThioacetazoneThioureaUreaAU1235epoxide hydrolaseisoxylmycobacteriummycolic acidsthiacetazone

Identifiers

PMID33809178
PMCPMC7998700
OpenAlexW3138450253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.