Evidence map›Paper›PMID 33809065›Full record

ArticleMarine drugs2021

Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β.

Shuwen Han, Chunlin Zhuang, Wei Zhou, Fener Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. A Review: Meridianins and Meridianins Derivatives.Molecules (Basel, Switzerland) · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shuwen HanInstitutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Chunlin ZhuangShanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.ORCID 0000-0002-0569-5708
Wei ZhouDepartment of Chemistry, Fudan University, Shanghai 200438, China.ORCID 0000-0001-7467-3628
Fener ChenInstitutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Fudan University · CN

Funding

Fudan University JIH1615060National Natural Science Foundation of China 22077018
6 · The paper itself

Abstract

Glycogen synthase kinase 3β (GSK-3β) is a widely investigated molecular target for numerous diseases, and inhibition of GSK-3β activity has become an attractive approach for the treatment of diabetes. Meridianin C, an indole-based natural product isolated from marine

Indexed as

AnimalsEnzyme InhibitorsGlucoseGlycogen Synthase Kinase 3 betaHep G2 CellsHumansIndolesPyrimidinesStructure-Activity RelationshipThiadiazolesUrochordata4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dioneEnzyme InhibitorsGlucoseGlycogen Synthase Kinase 3 betaIndolesmeridianin CPyrimidinesThiadiazolesdiabetesglucose uptakeglycogen synthase kinase 3βinhibitorstructural-based optimization

Identifiers

PMID33809065
PMCPMC7998309
OpenAlexW3138773294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.