Evidence map›Paper›PMID 33809026›Full record

ArticleMolecules (Basel, Switzerland)2021

Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber

Enas E Eltamany, Usama Ramadan Abdelmohsen, Dina M Hal, Amany K Ibrahim, Hashim A Hassanean, Reda F A Abdelhameed, Tarek A Temraz, Dina Hajjar, Arwa A Makki, Omnia Magdy Hendawy and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Enas E EltamanyDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0003-1607-4285
Usama Ramadan AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt.ORCID 0000-0002-1014-6922
Dina M HalDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Amany K IbrahimDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Hashim A HassaneanDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Reda F A AbdelhameedDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0002-1743-0942
Tarek A TemrazDepartment of Marine Science, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
Dina HajjarDepartment of Biochemistry, Collage of Science, University of Jeddah, Jeddah 80203, Saudi Arabia.
Arwa A MakkiDepartment of Biochemistry, Collage of Science, University of Jeddah, Jeddah 80203, Saudi Arabia.
Omnia Magdy HendawyDepartment of Chemistry of Pharmacology, Faculty of Pharmacy, Jouf University, Skaka 2014, Saudi Arabia.
Asmaa M AboulMagdPharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni Suef 62513, Egypt.ORCID 0000-0003-4243-9401
Khayrya A YoussifDepartment of Pharmacognosy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo 12585, Egypt.
Gerhard BringmannInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Safwat A AhmedDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical investigation of the methanolic extract of the Red Sea cucumber

Indexed as

AnimalsAntineoplastic AgentsBiological ProductsCerebrosidesComputer SimulationDrug Screening Assays, AntitumorHolothuriaHumansIn Vitro TechniquesMCF-7 CellsMolecular Docking SimulationMolecular StructureNuclear Magnetic Resonance, BiomolecularProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53Antineoplastic AgentsBiological ProductsCerebrosidesMDM2 protein, humanProto-Oncogene Proteins c-mdm2TP53 protein, humanTumor Suppressor Protein p53cerebrosidescytotoxicityHolothuria spiniferaHRMSmolecular docking

Identifiers

PMID33809026
PMCPMC8001240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.