Evidence map›Paper›PMID 33808974›Full record

ArticleBrain sciences2021

Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.

Rwei-Ling Yu, Shao-Ching Tu, Ruey-Meei Wu, Pei-An Lu, Chun-Hsiang Tan

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In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

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  9. Brain Glucose Metabolism andDiagnostics (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rwei-Ling YuInstitute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0001-5836-1237
Shao-Ching TuSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Ruey-Meei WuDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Pei-An LuDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chun-Hsiang TanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0001-6950-4678
Kaohsiung Medical University · TWNational Cheng Kung University · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 108-2320-B-037 -034 -MY3Ministry of Science and Technology, Taiwan MOST 108-2410-H-006-046-Ministry of Science and Technology, Taiwan MOST 108-2628-B-037-002 -
6 · The paper itself

Abstract

(1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause neurodegeneration. (2) Methods: To examine the effect of reduced activity of catechol-O-methyltransferase (COMT) and aldehyde dehydrogenase 2 (ALDH2) conferred by single nucleotide polymorphisms COMT rs4680(A) and ALDH2 rs671(A) on the symptoms of patients with Parkinson's disease (PD), a total of 114 PD patients were recruited cross-sectionally and received genotyping for rs4680 and rs671 along with MDS-UPDRS evaluation. (3) Results: We found that patients carrying rs4680(A) had more severe bradykinesia in the upper extremity and rest tremor. Besides, patients carrying rs671(A) had more difficulty maintaining personal hygiene, while patients with genotype rs671(GG) had higher scores in the item "depressed mood." More importantly, we found the effect of rs4680 to be moderated by rs671 SNP for the symptom of "hand movements." The detrimental impact of rs4680(A) is more pronounced in the presence of genotype rs671(GG). (4) Conclusions: This study facilitates a deeper understanding of the detrimental effect of reduced activity of COMT and ALDH2 conferred by genetic variation and provides novel insight into the interactions between enzymes metabolizing monoamine neurotransmitters in the pathogenesis of PD.

Indexed as

ALDH2bradykinesiaCOMTParkinson’s disease

Identifiers

PMID33808974
PMCPMC8001371
OpenAlexW3135521873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.